{"title":"Oligo Synthesis","description":"","products":[{"product_id":"dmt-2-o-moe-a-bz-ce-phosphoramidite","title":"DMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n    background: linear-gradient(to right, white, #162F65);\n    border: 0;\n    height: 1px;\n}\n.rte-des-lists {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 25px;\n    padding: 0 10px;\n    margin-bottom: 25px;\n}\n.rte-list-card {\n    flex: 1;\n    background: rgba(239, 238, 236, 0.3);\n    border-radius: 10px;\n    padding: 20px;\n    box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n    transition: transform 0.3s;\n    min-width: 290px;\n    position: relative;\n}\n.rte-list-card:hover {\n    transform: translateY(-5px);\n}\n.rte-list-icon {\n    width: 25px;\n    height: 25px;\n    margin: 0px 5px -5px 0px;\n    fill: currentColor;\n}\n.rte-list-card h3 {\n    font-size: 1.2em;\n    padding-bottom: 8px;\n    margin-bottom: 8px;\n    color: #3361ac;\n}\n.rte-dashed-list-title {\n    border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n    border-left: solid 3px #3361ac80;\n    padding: 3px 0 3px 10px;\n    margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n    width: 10px;\n    height: 10px;\n    margin-bottom: -5px;\n    fill: #3361ac80;\n}\n\n\u003c\/style\u003e\n\u003cp\u003eDMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a benzoyl (Bz) base-protecting group on adenine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"rte-list-icon\"\u003e\n        \u003cpath d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"rte-list-icon\"\u003e\n        \u003cpath d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 640 640\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 20px;\" class=\"rte-list-feature\"\u003eFast-deprotection variants available upon request \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541323378888,"sku":"PR1-004-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541323411656,"sku":"PR1-004-05A","price":21.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541323444424,"sku":"PR1-004-1A","price":25.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541323477192,"sku":"PR1-004-5B","price":68.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541323509960,"sku":"PR1-004-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541323542728,"sku":"PR1-004-25C","price":290.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541323575496,"sku":"PR1-004-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541323608264,"sku":"PR1-004-200D","price":1900.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR1-004_8b863a06-cb32-4843-b24c-7ac28949e422.jpg?v=1748589703"},{"product_id":"dmt-2-o-moe-g-ibu-ce-phosphoramidite","title":"DMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n    background: linear-gradient(to right, white, #162F65);\n    border: 0;\n    height: 1px;\n}\n.rte-des-lists {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 25px;\n    padding: 0 10px;\n    margin-bottom: 25px;\n}\n.rte-list-card {\n    flex: 1;\n    background: rgba(239, 238, 236, 0.3);\n    border-radius: 10px;\n    padding: 20px;\n    box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n    transition: transform 0.3s;\n    min-width: 290px;\n    position: relative;\n}\n.rte-list-card:hover {\n    transform: translateY(-5px);\n}\n.rte-list-icon {\n    width: 25px;\n    height: 25px;\n    margin: 0px 5px -5px 0px;\n    fill: currentColor;\n}\n.rte-list-card h3 {\n    font-size: 1.2em;\n    padding-bottom: 8px;\n    margin-bottom: 8px;\n    color: #3361ac;\n}\n.rte-dashed-list-title {\n    border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n    border-left: solid 3px #3361ac80;\n    padding: 3px 0 3px 10px;\n    margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n    width: 10px;\n    height: 10px;\n    margin-bottom: -5px;\n    fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003eDMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a isobutyryl (iBu) base-protecting group on guanine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"rte-list-icon\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541323673800,"sku":"PR2-006-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541323706568,"sku":"PR2-006-05A","price":21.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541323739336,"sku":"PR2-006-1A","price":25.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541323772104,"sku":"PR2-006-5B","price":67.5,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541323804872,"sku":"PR2-006-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541323837640,"sku":"PR2-006-25C","price":290.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541323870408,"sku":"PR2-006-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541323903176,"sku":"PR2-006-200D","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR2-006_e0576077-be37-4fa6-9d26-9b1b60a81ad6.jpg?v=1748589702"},{"product_id":"dmt-2-o-moe-g-dmf-ce-phosphoramidite","title":"DMT-2'-O-MOE-G(dmf)-CE-Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541323935944,"sku":"PR2-019","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR2-019_4e28a16a-d113-42b9-b26e-710917ceff8f.jpg?v=1748589701"},{"product_id":"5-me-dmt-2-o-moe-c-bz-ce-phosphoramidite","title":"5-Me-DMT-2'-O-MOE-C(Bz)-CE-Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n    background: linear-gradient(to right, white, #162F65);\n    border: 0;\n    height: 1px;\n}\n.rte-des-lists {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 25px;\n    padding: 0 10px;\n    margin-bottom: 25px;\n}\n.rte-list-card {\n    flex: 1;\n    background: rgba(239, 238, 236, 0.3);\n    border-radius: 10px;\n    padding: 20px;\n    box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n    transition: transform 0.3s;\n    min-width: 290px;\n    position: relative;\n}\n.rte-list-card:hover {\n    transform: translateY(-5px);\n}\n.rte-list-icon {\n    width: 25px;\n    height: 25px;\n    margin: 0px 5px -5px 0px;\n    fill: currentColor;\n}\n.rte-list-card h3 {\n    font-size: 1.2em;\n    padding-bottom: 8px;\n    margin-bottom: 8px;\n    color: #3361ac;\n}\n.rte-dashed-list-title {\n    border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n    border-left: solid 3px #3361ac80;\n    padding: 3px 0 3px 10px;\n    margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n    width: 10px;\n    height: 10px;\n    margin-bottom: -5px;\n    fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003e5-Me-DMT-2'-O-MOE-C(Bz)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a benzoyl (Bz) base-protecting group on 5-methylcytosine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 640 640\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] 2.Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541323968712,"sku":"PR3-007-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541324001480,"sku":"PR3-007-05A","price":20.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541324034248,"sku":"PR3-007-1A","price":23.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541324067016,"sku":"PR3-007-5B","price":68.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541324099784,"sku":"PR3-007-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541324132552,"sku":"PR3-007-25C","price":295.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541324165320,"sku":"PR3-007-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541324198088,"sku":"PR3-007-200D","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR3-007_240f25f3-4b54-4b4e-9e0b-f0178b24c195.jpg?v=1748589700"},{"product_id":"5-me-dmt-2-o-moe-c-ac-ce-phosphoramidite","title":"5-Me-DMT-2'-O-MOE-C(Ac)-CE-Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n    background: linear-gradient(to right, white, #162F65);\n    border: 0;\n    height: 1px;\n}\n.rte-des-lists {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 25px;\n    padding: 0 10px;\n    margin-bottom: 25px;\n}\n.rte-list-card {\n    flex: 1;\n    background: rgba(239, 238, 236, 0.3);\n    border-radius: 10px;\n    padding: 20px;\n    box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n    transition: transform 0.3s;\n    min-width: 290px;\n    position: relative;\n}\n.rte-list-card:hover {\n    transform: translateY(-5px);\n}\n.rte-list-icon {\n    width: 25px;\n    height: 25px;\n    margin: 0px 5px -5px 0px;\n    fill: currentColor;\n}\n.rte-list-card h3 {\n    font-size: 1.2em;\n    padding-bottom: 8px;\n    margin-bottom: 8px;\n    color: #3361ac;\n}\n.rte-dashed-list-title {\n    border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n    border-left: solid 3px #3361ac80;\n    padding: 3px 0 3px 10px;\n    margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n    width: 10px;\n    height: 10px;\n    margin-bottom: -5px;\n    fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003e5-Me-DMT-2'-O-MOE-C(Ac)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, acetyl (Ac) base-protecting group on 5-methylcytosine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 640 640\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] 2.Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541324361928,"sku":"PR3-017-025A","price":300.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541324394696,"sku":"PR3-017-05A","price":375.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541324427464,"sku":"PR3-017-1A","price":375.0,"currency_code":"USD","in_stock":false},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541324460232,"sku":"PR3-017-5B","price":550.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541324493000,"sku":"PR3-017-10B","price":700.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541324525768,"sku":"PR3-017-25C","price":2800.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541324558536,"sku":"PR3-017-100C","price":9000.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541324591304,"sku":"PR3-017-200D","price":17000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR3-017_2ba4fc39-65d0-4b7e-b6e0-ee6941e8a811.jpg?v=1748589698"},{"product_id":"dmt-2-o-moe-t-ce-phosphoramidite","title":"DMT-2'-O-MOE-T-CE-Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n    background: linear-gradient(to right, white, #162F65);\n    border: 0;\n    height: 1px;\n}\n.rte-des-lists {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 25px;\n    padding: 0 10px;\n    margin-bottom: 25px;\n}\n.rte-list-card {\n    flex: 1;\n    background: rgba(239, 238, 236, 0.3);\n    border-radius: 10px;\n    padding: 20px;\n    box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n    transition: transform 0.3s;\n    min-width: 290px;\n    position: relative;\n}\n.rte-list-card:hover {\n    transform: translateY(-5px);\n}\n.rte-list-icon {\n    width: 25px;\n    height: 25px;\n    margin: 0px 5px -5px 0px;\n    fill: currentColor;\n}\n.rte-list-card h3 {\n    font-size: 1.2em;\n    padding-bottom: 8px;\n    margin-bottom: 8px;\n    color: #3361ac;\n}\n.rte-dashed-list-title {\n    border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n    border-left: solid 3px #3361ac80;\n    padding: 3px 0 3px 10px;\n    margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n    width: 10px;\n    height: 10px;\n    margin-bottom: -5px;\n    fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003eDMT-2'-O-MOE-T-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a thymine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n        \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"rte-list-icon\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541325082824,"sku":"PR4-002-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541325115592,"sku":"PR4-002-05A","price":21.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541325148360,"sku":"PR4-002-1A","price":25.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541325181128,"sku":"PR4-002-5B","price":68.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541325213896,"sku":"PR4-002-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541325246664,"sku":"PR4-002-25C","price":295.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541325279432,"sku":"PR4-002-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541325312200,"sku":"PR4-002-200D","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR4-002_c84af093-70e5-46eb-9e00-139abb1539d6.jpg?v=1748589697"},{"product_id":"5-me-5-o-dmt-2-o-moe-cr-3-ce-phosphoramidite","title":"5-Me-5'-O-DMT-2'-O-MOE-Cr 3'-CE-Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541325541576,"sku":"PR3-024","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR3-024_eb8115a0-b92f-4a22-88c1-e35bf02f8aba.jpg?v=1748589696"},{"product_id":"abasic-moe-amidite-a-b-mix","title":"Abasic MOE amidite (α, β mix)","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541325574344,"sku":"OP-029","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/OP-029_a055e756-5022-4241-9213-3ffee2093892.jpg?v=1748589695"},{"product_id":"dmt-2-o-moe-ar-ce-phosphoramidite","title":"DMT-2'-O-MOE-Ar-CE-Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N 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