{"title":"Phosphoramidites","description":"\u003cstyle\u003e\n.collection-des-section {\n margin-bottom: 30px;\n}\n.section-title {\n color: #3361ac;\n font-size: 1.5em;\n}\n\/* Introduction Section *\/\n.intro-content {\n display: block;\n min-height: 380px;\n}\n.intro-content p {\n margin-bottom: 15px;\n}\n.structure-diagram {\n background: rgba(193, 212, 231, 0.15);\n border-radius: 10px;\n padding: 20px;\n text-align: center;\n box-shadow: 0 3px 10px rgba(22, 47, 101, 0.2);\n color: rgba(22, 47, 101, 0.7);\n font-style: italic;\n font-weight: 500;\n font-size: 12px;\n width: 340px;\n float: right;\n margin: 0 10px 20px 20px;\n}\n.structure-placeholder {\n width: 100%;\n background: #ffffff;\n border-radius: 8px;\n display: flex;\n align-items: center;\n justify-content: center;\n margin-bottom: 15px;\n}\n\/*horizontal ray*\/\n.collection-des-hr {\n background: linear-gradient(to right, #ffffff, #3361ac);\n border: 0;\n height: 2px;\n margin: 10px 0 25px;\n}\n\/* Advantages Section 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class=\"intro-text\"\u003e\n\u003cdiv class=\"structure-diagram\"\u003e\n\u003cdiv class=\"structure-placeholder\"\u003e\u003csvg version=\"1.1\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 231 137\" height=\"250px\"\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 153.564 41.4902)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e O\u003c\/text\u003e\n \u003cpath d=\"M 3331.08,2004.67 L 3353.39,2024.67 L 3347.39,2044.67 L 2755.44,2044.67 L 2749.44,2024.67 L 2771.79,2004.67 L 3331.08,2004.67 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 3525.72,1816.36 L 3536.72,1814.04 L 3542.72,1815.96 L 3359.39,2067.15 L 3353.39,2024.67 L 3331.08,2004.67 L 3525.72,1816.36 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 3147.06,1675.98 L 3151.23,1664.73 L 3530.72,1805.41 L 3536.72,1814.04 L 3525.72,1816.36 L 3147.06,1675.98 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 2573.4,1816.34 L 2562.3,1814.04 L 2568.3,1805.43 L 2950.61,1664.43 L 2954.76,1675.69 L 2573.4,1816.34 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 2556.3,1815.99 L 2562.3,1814.04 L 2573.4,1816.34 L 2771.79,2004.67 L 2749.44,2024.67 L 2743.44,2066.59 L 2556.3,1815.99 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 179.741 93.8268)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e X\u003c\/text\u003e\n \u003cpath d=\"M 3359.39,2167.25 L 3347.39,2167.25 L 3347.39,2044.67 L 3353.39,2024.67 L 3359.39,2067.15 L 3359.39,2167.25 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 128.453 93.8268)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e O\u003c\/text\u003e\n \u003cpath d=\"M 2755.44,2164.75 L 2743.44,2164.75 L 2743.44,2066.59 L 2749.44,2024.67 L 2755.44,2044.67 L 2755.44,2164.75 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 2556.3,1529.5 L 2568.3,1522.58 L 2568.3,1805.43 L 2562.3,1814.04 L 2556.3,1815.99 L 2556.3,1529.5 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 45.1836 17.4902)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e DMTrO\u003c\/text\u003e\n \u003cpath d=\"M 2334.75,1401.36 L 2340.75,1390.97 L 2568.3,1522.58 L 2556.3,1529.5 L 2334.75,1401.36 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 195.018 32.5031)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e B\u003c\/text\u003e\n \u003cpath d=\"M 3530.72,1635.04 L 3542.72,1635.04 L 3542.72,1815.96 L 3536.72,1814.04 L 3530.72,1805.41 L 3530.72,1635.04 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 215.803 20.5031)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e P\u003c\/text\u003e\n \u003cpath d=\"M 3686.22,1432.79 L 3692.22,1443.18 L 3619.74,1485.03 L 3613.74,1474.64 L 3686.22,1432.79 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 108.627 105.827)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e P\u003c\/text\u003e\n \u003cpath d=\"M 2589.02,2361.47 L 2583.02,2351.08 L 2653.76,2310.23 L 2659.76,2320.62 L 2589.02,2361.47 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 108.169 129.827)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e N(iPr)\u003c\/text\u003e\n \u003ctext style=\"font:normal normal normal 150px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 151.774 133.493)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e 2\u003c\/text\u003e\n \u003cpath d=\"M 2506.02,2599.75 L 2494.02,2599.75 L 2494.02,2515.25 L 2506.02,2515.25 L 2506.02,2599.75 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 86.884 93.8268)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e O\u003c\/text\u003e\n \u003cpath d=\"M 2340.72,2320.87 L 2346.72,2310.48 L 2410.3,2347.19 L 2404.3,2357.58 L 2340.72,2320.87 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 2001.19,2412.85 L 2001.19,2398.99 L 2154.93,2310.23 L 2160.93,2320.62 L 2001.19,2412.85 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 1751.78,2268.85 L 1751.78,2254.99 L 2001.19,2398.99 L 2001.19,2412.85 L 1751.78,2268.85 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 1502.36,2412.85 L 1502.36,2398.99 L 1751.78,2254.99 L 1751.78,2268.85 L 1502.36,2412.85 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003ctext style=\"font:normal normal normal 200px 'Arial'\" transform=\"matrix(0.0833333 0 0 0.0833333 4.24564 93.8268)\" fill=\"#000000\" stroke=\"transparent\" y=\"0\" x=\"0\"\u003e N\u003c\/text\u003e\n \u003cpath d=\"M 1326.36,2371.09 L 1332.36,2360.7 L 1479.44,2445.62 L 1473.44,2456.01 L 1326.36,2371.09 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 1352.28,2326.2 L 1358.28,2315.81 L 1502.36,2398.99 L 1502.36,2412.85 L 1352.28,2326.2 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003cpath d=\"M 1378.2,2281.3 L 1384.2,2270.91 L 1531.28,2355.83 L 1525.28,2366.22 L 1378.2,2281.3 Z\" transform=\"matrix(0.0833333 0 0 0.0833333 -94.1667 -101.167)\" fill=\"#000000\" stroke=\"transparent\"\u003e\u003c\/path\u003e\n \u003c\/svg\u003e\u003c\/div\u003e\n\u003cp\u003eAn example phosphoramidite structure consists of a 5' - protected DMTrO group, a sugar ring, a phosphoramidite moiety (containing diisopropylamino, etc.), and base - related parts.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cstrong\u003eWhat are Phosphoramidites?\u003c\/strong\u003e\u003cbr\u003ePhosphoramidites are specialized chemical compounds that serve as the essential building blocks in automated solid-phase oligonucleotide synthesis. These molecules consist of a nucleoside (adenosine, guanosine, cytidine, thymidine, or uridine, often with protective groups and sugar modifications) attached to a reactive phosphoramidite group, typically with a dialkylamine moiety (e.g., diisopropylamine) that acts as the leaving group during coupling reactions.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eSynthesis and Key Characteristics\u003c\/strong\u003e\u003cbr\u003eOur phosphoramidites are manufactured through a meticulous multi-step process:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cem\u003eNucleoside Preparation:\u003c\/em\u003e Starting nucleosides are carefully protected at exocyclic amines (with groups like acetyl, benzoyl, or isobutyryl) and at the 5'-hydroxyl position (typically with DMTr or MMTr groups) to prevent undesired reactions during synthesis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003ePhosphitylation:\u003c\/em\u003e The protected nucleoside reacts with a phosphitylating reagent (e.g., 2-cyanoethyl N,N-diisopropylchlorophosphoramidite) under controlled anhydrous conditions to form the phosphoramidite.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003ePurification and Stabilization:\u003c\/em\u003e The crude product undergoes rigorous purification through chromatography and\/or crystallization. Stabilizers may be added to enhance shelf life.\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eQuality Control:\u003c\/em\u003e Each batch undergoes comprehensive analysis including HPLC for purity assessment, ³¹P NMR to confirm phosphoramidite structure and purity, and moisture analysis to ensure stability.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eApplication in Oligonucleotide Synthesis\u003c\/strong\u003e\u003cbr\u003ePhosphoramidites are designed for use in automated synthesizers following a four-step cycle:\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cem\u003eDetritylation:\u003c\/em\u003e Acidic removal of the 5'-protecting group (DMTr)\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eCoupling:\u003c\/em\u003e Activation with weak acid (e.g., tetrazole) enables nucleophilic attack by the free 5'-OH of the growing chain, forming a phosphite triester linkage\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eCapping:\u003c\/em\u003e Acetylation of unreacted chains prevents deletion sequences\u003c\/li\u003e\n\u003cli\u003e\n\u003cem\u003eOxidation:\u003c\/em\u003e Conversion of the phosphite triester to a more stable phosphate triester\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c!-- Advantages Section --\u003e\n\u003cdiv class=\"collection-des-section\"\u003e\n\u003ch2 class=\"section-title\"\u003eOur Advantages\u003c\/h2\u003e\n\u003chr class=\"collection-des-hr\"\u003e\n\u003cdiv class=\"collection-des-lists\"\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"list-icon\"\u003e\n \u003cpath d=\"M384 64L224 64C206.3 64 192 78.3 192 96C192 113.7 206.3 128 224 128L224 279.5L103.5 490.3C98.6 499 96 508.7 96 518.7C96 550.4 121.6 576 153.3 576L486.7 576C518.3 576 544 550.4 544 518.7C544 508.7 541.4 498.9 536.5 490.3L416 279.5L416 128C433.7 128 448 113.7 448 96C448 78.3 433.7 64 416 64L384 64zM288 279.5L288 128L352 128L352 279.5C352 290.6 354.9 301.6 360.4 311.3L402 384L238 384L279.6 311.3C285.1 301.6 288 290.7 288 279.5z\" fill=\"currentColor\"\u003e\u003c\/path\u003e\n \u003c\/svg\u003e High Purity \u0026amp; Structural Integrity\u003c\/h3\u003e\n\u003cp\u003eEvery batch of none-customization amidites achieves a typical purity up to ≥98%, as verified by advanced analytical techniques including HPLC and ³¹P NMR spectroscopy.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"list-icon\"\u003e\n \u003cpath d=\"M434.8 54.1C446.7 62.7 451.1 78.3 445.7 91.9L367.3 288L512 288C525.5 288 537.5 296.4 542.1 309.1C546.7 321.8 542.8 336 532.5 344.6L244.5 584.6C233.2 594 217.1 594.5 205.2 585.9C193.3 577.3 188.9 561.7 194.3 548.1L272.7 352L128 352C114.5 352 102.5 343.6 97.9 330.9C93.3 318.2 97.2 304 107.5 295.4L395.5 55.4C406.8 46 422.9 45.5 434.8 54.1z\" fill=\"currentColor\"\u003e\u003c\/path\u003e\n \u003c\/svg\u003e Exceptional Coupling Efficiency\u003c\/h3\u003e\n\u003cp\u003eOur phosphoramidites consistently achieve excellent coupling efficiencies, enabling synthesis of long and complex oligonucleotides with high yields and minimal failure sequences.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3\u003e\n\u003csvg viewbox=\"0 0 16 16\" fill=\"currentColor\" class=\"list-icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"\u003e\n \u003cpath d=\"M5 11.5a.5.5 0 0 1 .5-.5h9a.5.5 0 0 1 0 1h-9a.5.5 0 0 1-.5-.5m0-4a.5.5 0 0 1 .5-.5h9a.5.5 0 0 1 0 1h-9a.5.5 0 0 1-.5-.5m0-4a.5.5 0 0 1 .5-.5h9a.5.5 0 0 1 0 1h-9a.5.5 0 0 1-.5-.5M3.854 2.146a.5.5 0 0 1 0 .708l-1.5 1.5a.5.5 0 0 1-.708 0l-.5-.5a.5.5 0 1 1 .708-.708L2 3.293l1.146-1.147a.5.5 0 0 1 .708 0m0 4a.5.5 0 0 1 0 .708l-1.5 1.5a.5.5 0 0 1-.708 0l-.5-.5a.5.5 0 1 1 .708-.708L2 7.293l1.146-1.147a.5.5 0 0 1 .708 0m0 4a.5.5 0 0 1 0 .708l-1.5 1.5a.5.5 0 0 1-.708 0l-.5-.5a.5.5 0 0 1 .708-.708l.146.147 1.146-1.147a.5.5 0 0 1 .708 0\" fill-rule=\"evenodd\"\u003e\u003c\/path\u003e\n \u003c\/svg\u003e Comprehensive Portfolio\u003c\/h3\u003e\n\u003cp\u003eWe offer standard and modified phosphoramidites (including 2'-O-methyl, 2'-fluoro, LNA, and many other modifications) to meet diverse research and therapeutic development needs.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c!-- Applications Section --\u003e\n\u003cdiv class=\"collection-des-section\" id=\"application-field\"\u003e\n\u003ch3 class=\"section-title\"\u003ePowering Innovation Across Life Sciences\u003c\/h3\u003e\n\u003cp\u003eOur phosphoramidites are trusted by scientists worldwide to synthesize oligonucleotides for a vast range of cutting-edge applications\u003c\/p\u003e\n\u003chr class=\"collection-des-hr\"\u003e\n\u003cdiv class=\"collection-des-lists\"\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3 class=\"dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"list-icon\"\u003e\n \u003cpath d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Therapeutic Development\u003c\/h3\u003e\n\u003cp\u003eSynthesize critical components for siRNA, antisense oligonucleotides (ASOs), and aptamers for novel drug discovery and development. Our high-purity phosphoramidites ensure the reliability and efficacy of therapeutic oligonucleotides.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3 class=\"dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"list-icon\"\u003e\n \u003cpath d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Diagnostics \u0026amp; PCR\u003c\/h3\u003e\n\u003cp\u003eProduce highly specific PCR primers, probes, and capture sequences for molecular diagnostics and genetic testing. Achieve exceptional accuracy and reproducibility with our consistent quality.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3 class=\"dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"list-icon\"\u003e\n \u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Research Tools\u003c\/h3\u003e\n\u003cp\u003eEnable foundational research in genomics, including gene synthesis, mutagenesis studies, and NGS library preparation. Our products support academic and industrial research with reliable performance.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3 class=\"dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-icon\"\u003e\n \u003cpath d=\"M566.6 470.6L470.6 566.6C461.4 575.8 447.7 578.5 435.7 573.5C423.7 568.5 416 556.9 416 544L416 480L96 480C78.3 480 64 465.7 64 448C64 430.3 78.3 416 96 416L416 416L416 352C416 339.1 423.8 327.4 435.8 322.4C447.8 317.4 461.5 320.2 470.7 329.3L566.7 425.3C579.2 437.8 579.2 458.1 566.7 470.6zM73.4 214.6C60.9 202.1 60.9 181.8 73.4 169.3L169.4 73.3C178.6 64.1 192.3 61.4 204.3 66.4C216.3 71.4 224 83.1 224 96L224 160L544 160C561.7 160 576 174.3 576 192C576 209.7 561.7 224 544 224L224 224L224 288C224 300.9 216.2 312.6 204.2 317.6C192.2 322.6 178.5 319.8 169.3 310.7L73.3 214.7z\"\u003e\u003c\/path\u003e\n \u003c\/svg\u003e Next-Generation Sequencing\u003c\/h3\u003e\n\u003cp\u003eManufacture of primers, adapters, and other oligonucleotides used in NGS library preparation and target enrichment.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3 class=\"dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-icon\"\u003e\n \u003cpath d=\"M256 320L216.5 359.5C203.9 354.6 190.3 352 176 352C114.1 352 64 402.1 64 464C64 525.9 114.1 576 176 576C237.9 576 288 525.9 288 464C288 449.7 285.3 436.1 280.5 423.5L563.2 140.8C570.3 133.7 570.3 122.3 563.2 115.2C534.9 86.9 489.1 86.9 460.8 115.2L320 256L280.5 216.5C285.4 203.9 288 190.3 288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176C64 237.9 114.1 288 176 288C190.3 288 203.9 285.3 216.5 280.5L256 320zM353.9 417.9L460.8 524.8C489.1 553.1 534.9 553.1 563.2 524.8C570.3 517.7 570.3 506.3 563.2 499.2L417.9 353.9L353.9 417.9zM128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176C224 202.5 202.5 224 176 224C149.5 224 128 202.5 128 176zM176 416C202.5 416 224 437.5 224 464C224 490.5 202.5 512 176 512C149.5 512 128 490.5 128 464C128 437.5 149.5 416 176 416z\"\u003e\u003c\/path\u003e\n \u003c\/svg\u003e CRISPR\/Cas Systems\u003c\/h3\u003e\n\u003cp\u003eProduction of guide RNAs (gRNAs) and related components for genome editing applications.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"list-card\"\u003e\n\u003ch3 class=\"dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-icon\"\u003e\n \u003cpath d=\"M240 64C213.5 64 192 85.5 192 112L192 320C192 346.5 213.5 368 240 368L304 368C330.5 368 352 346.5 352 320L352 256L384 256C454.7 256 512 313.3 512 384C512 454.7 454.7 512 384 512L96 512C78.3 512 64 526.3 64 544C64 561.7 78.3 576 96 576L544 576C561.7 576 576 561.7 576 544C576 526.3 561.7 512 544 512L527.1 512C557.5 478 576 433.2 576 384C576 278 490 192 384 192L352 192L352 112C352 85.5 330.5 64 304 64L240 64zM184 416C170.7 416 160 426.7 160 440C160 453.3 170.7 464 184 464L360 464C373.3 464 384 453.3 384 440C384 426.7 373.3 416 360 416L184 416z\"\u003e\u003c\/path\u003e\n \u003c\/svg\u003e Nanotechnology\u003c\/h3\u003e\n\u003cp\u003eFabrication of DNA origami and other nucleic acid nanostructures for material science and drug delivery applications.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","products":[{"product_id":"dmt-2-o-moe-a-bz-ce-phosphoramidite","title":"DMT-2'-O-MOE-A(Bz)-CE Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n background: linear-gradient(to right, white, #162F65);\n border: 0;\n height: 1px;\n}\n.rte-des-lists {\n display: flex;\n flex-wrap: wrap;\n gap: 25px;\n padding: 0 10px;\n margin-bottom: 25px;\n}\n.rte-list-card {\n flex: 1;\n background: rgba(239, 238, 236, 0.3);\n border-radius: 10px;\n padding: 20px;\n box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n transition: transform 0.3s;\n min-width: 290px;\n position: relative;\n}\n.rte-list-card:hover {\n transform: translateY(-5px);\n}\n.rte-list-icon {\n width: 25px;\n height: 25px;\n margin: 0px 5px -5px 0px;\n fill: currentColor;\n}\n.rte-list-card h3 {\n font-size: 1.2em;\n padding-bottom: 8px;\n margin-bottom: 8px;\n color: #3361ac;\n}\n.rte-dashed-list-title {\n border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n border-left: solid 3px #3361ac80;\n padding: 3px 0 3px 10px;\n margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n width: 10px;\n height: 10px;\n margin-bottom: -5px;\n fill: #3361ac80;\n}\n\n\u003c\/style\u003e\n\u003cp\u003eDMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a benzoyl (Bz) base-protecting group on adenine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"rte-list-icon\"\u003e\n \u003cpath d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" class=\"rte-list-icon\"\u003e\n \u003cpath d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 640 640\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"margin-bottom: 20px;\" class=\"rte-list-feature\"\u003eFast-deprotection variants available upon request \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541323378888,"sku":"PR1-004-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541323411656,"sku":"PR1-004-05A","price":21.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541323444424,"sku":"PR1-004-1A","price":25.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541323477192,"sku":"PR1-004-5B","price":68.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541323509960,"sku":"PR1-004-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541323542728,"sku":"PR1-004-25C","price":290.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541323575496,"sku":"PR1-004-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541323608264,"sku":"PR1-004-200D","price":1900.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR1-004_8b863a06-cb32-4843-b24c-7ac28949e422.jpg?v=1748589703"},{"product_id":"dmt-2-o-moe-g-ibu-ce-phosphoramidite","title":"DMT-2'-O-MOE-G(iBu)-CE Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n background: linear-gradient(to right, white, #162F65);\n border: 0;\n height: 1px;\n}\n.rte-des-lists {\n display: flex;\n flex-wrap: wrap;\n gap: 25px;\n padding: 0 10px;\n margin-bottom: 25px;\n}\n.rte-list-card {\n flex: 1;\n background: rgba(239, 238, 236, 0.3);\n border-radius: 10px;\n padding: 20px;\n box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n transition: transform 0.3s;\n min-width: 290px;\n position: relative;\n}\n.rte-list-card:hover {\n transform: translateY(-5px);\n}\n.rte-list-icon {\n width: 25px;\n height: 25px;\n margin: 0px 5px -5px 0px;\n fill: currentColor;\n}\n.rte-list-card h3 {\n font-size: 1.2em;\n padding-bottom: 8px;\n margin-bottom: 8px;\n color: #3361ac;\n}\n.rte-dashed-list-title {\n border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n border-left: solid 3px #3361ac80;\n padding: 3px 0 3px 10px;\n margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n width: 10px;\n height: 10px;\n margin-bottom: -5px;\n fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003eDMT-2'-O-MOE-G(iBu)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a isobutyryl (iBu) base-protecting group on guanine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"rte-list-icon\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541323673800,"sku":"PR2-006-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541323706568,"sku":"PR2-006-05A","price":21.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541323739336,"sku":"PR2-006-1A","price":25.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541323772104,"sku":"PR2-006-5B","price":67.5,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541323804872,"sku":"PR2-006-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541323837640,"sku":"PR2-006-25C","price":290.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541323870408,"sku":"PR2-006-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541323903176,"sku":"PR2-006-200D","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR2-006_e0576077-be37-4fa6-9d26-9b1b60a81ad6.jpg?v=1748589702"},{"product_id":"dmt-2-o-moe-g-dmf-ce-phosphoramidite","title":"DMT-2'-O-MOE-G(dmf)-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541323935944,"sku":"PR2-019","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR2-019_4e28a16a-d113-42b9-b26e-710917ceff8f.jpg?v=1748589701"},{"product_id":"5-me-dmt-2-o-moe-c-bz-ce-phosphoramidite","title":"5-Me-DMT-2'-O-MOE-C(Bz)-CE Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n background: linear-gradient(to right, white, #162F65);\n border: 0;\n height: 1px;\n}\n.rte-des-lists {\n display: flex;\n flex-wrap: wrap;\n gap: 25px;\n padding: 0 10px;\n margin-bottom: 25px;\n}\n.rte-list-card {\n flex: 1;\n background: rgba(239, 238, 236, 0.3);\n border-radius: 10px;\n padding: 20px;\n box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n transition: transform 0.3s;\n min-width: 290px;\n position: relative;\n}\n.rte-list-card:hover {\n transform: translateY(-5px);\n}\n.rte-list-icon {\n width: 25px;\n height: 25px;\n margin: 0px 5px -5px 0px;\n fill: currentColor;\n}\n.rte-list-card h3 {\n font-size: 1.2em;\n padding-bottom: 8px;\n margin-bottom: 8px;\n color: #3361ac;\n}\n.rte-dashed-list-title {\n border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n border-left: solid 3px #3361ac80;\n padding: 3px 0 3px 10px;\n margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n width: 10px;\n height: 10px;\n margin-bottom: -5px;\n fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003e5-Me-DMT-2'-O-MOE-C(Bz)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a benzoyl (Bz) base-protecting group on 5-methylcytosine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 640 640\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] 2.Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541323968712,"sku":"PR3-007-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541324001480,"sku":"PR3-007-05A","price":20.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541324034248,"sku":"PR3-007-1A","price":23.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541324067016,"sku":"PR3-007-5B","price":68.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541324099784,"sku":"PR3-007-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541324132552,"sku":"PR3-007-25C","price":295.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541324165320,"sku":"PR3-007-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541324198088,"sku":"PR3-007-200D","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR3-007_240f25f3-4b54-4b4e-9e0b-f0178b24c195.jpg?v=1748589700"},{"product_id":"5-me-dmt-2-o-moe-c-ac-ce-phosphoramidite","title":"5-Me-DMT-2'-O-MOE-C(Ac)-CE Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n background: linear-gradient(to right, white, #162F65);\n border: 0;\n height: 1px;\n}\n.rte-des-lists {\n display: flex;\n flex-wrap: wrap;\n gap: 25px;\n padding: 0 10px;\n margin-bottom: 25px;\n}\n.rte-list-card {\n flex: 1;\n background: rgba(239, 238, 236, 0.3);\n border-radius: 10px;\n padding: 20px;\n box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n transition: transform 0.3s;\n min-width: 290px;\n position: relative;\n}\n.rte-list-card:hover {\n transform: translateY(-5px);\n}\n.rte-list-icon {\n width: 25px;\n height: 25px;\n margin: 0px 5px -5px 0px;\n fill: currentColor;\n}\n.rte-list-card h3 {\n font-size: 1.2em;\n padding-bottom: 8px;\n margin-bottom: 8px;\n color: #3361ac;\n}\n.rte-dashed-list-title {\n border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n border-left: solid 3px #3361ac80;\n padding: 3px 0 3px 10px;\n margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n width: 10px;\n height: 10px;\n margin-bottom: -5px;\n fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003e5-Me-DMT-2'-O-MOE-C(Ac)-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, acetyl (Ac) base-protecting group on 5-methylcytosine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 640 640\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] 2.Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541324361928,"sku":"PR3-017-025A","price":300.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541324394696,"sku":"PR3-017-05A","price":375.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541324427464,"sku":"PR3-017-1A","price":375.0,"currency_code":"USD","in_stock":false},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541324460232,"sku":"PR3-017-5B","price":550.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541324493000,"sku":"PR3-017-10B","price":700.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541324525768,"sku":"PR3-017-25C","price":2800.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541324558536,"sku":"PR3-017-100C","price":9000.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541324591304,"sku":"PR3-017-200D","price":17000.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR3-017_2ba4fc39-65d0-4b7e-b6e0-ee6941e8a811.jpg?v=1748589698"},{"product_id":"dmt-2-o-moe-t-ce-phosphoramidite","title":"DMT-2'-O-MOE-T-CE Phosphoramidite \/ 5-Me-DMT-2'-O-MOE-U-CE Phosphoramidite","description":"\u003cstyle\u003e\n.rte-hr {\n background: linear-gradient(to right, white, #162F65);\n border: 0;\n height: 1px;\n}\n.rte-des-lists {\n display: flex;\n flex-wrap: wrap;\n gap: 25px;\n padding: 0 10px;\n margin-bottom: 25px;\n}\n.rte-list-card {\n flex: 1;\n background: rgba(239, 238, 236, 0.3);\n border-radius: 10px;\n padding: 20px;\n box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n transition: transform 0.3s;\n min-width: 290px;\n position: relative;\n}\n.rte-list-card:hover {\n transform: translateY(-5px);\n}\n.rte-list-icon {\n width: 25px;\n height: 25px;\n margin: 0px 5px -5px 0px;\n fill: currentColor;\n}\n.rte-list-card h3 {\n font-size: 1.2em;\n padding-bottom: 8px;\n margin-bottom: 8px;\n color: #3361ac;\n}\n.rte-dashed-list-title {\n border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n border-left: solid 3px #3361ac80;\n padding: 3px 0 3px 10px;\n margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n width: 10px;\n height: 10px;\n margin-bottom: -5px;\n fill: #3361ac80;\n}\n\u003c\/style\u003e\n\u003cp\u003eDMT-2'-O-MOE-T-CE-Phosphoramidite is a 2'-MOE phosphoramidite monomer used for solid-phase oligonucleotide synthesis. It contains a 5'-dimethoxytrityl (DMT) protecting group for 5'-hydroxyl protection, a thymine, a cyanoethyl (CE) protecting group on phosphite, and a \u003cstrong\u003e2'-O-methoxyethyl (MOE)\u003c\/strong\u003e modification.\u003c\/p\u003e\n\u003cp\u003e2'-O-MOE provide \u003cstrong\u003eenhanced nuclease resistance, duplex stability, and low cytotoxicity\u003c\/strong\u003e compared with unmodified RNA.\u003c\/p\u003e\n\u003cp\u003eStructurally, the 2'-hydroxyl group of ribose is replaced by a \u003cem\u003e–O–CH₂–CH₂–O–CH₃\u003c\/em\u003e (methoxyethyl) group, which locks the sugar into an RNA-like C3'-endo conformation and stabilizes hybrid formation with complementary RNA strands.\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eApplications\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e RNase H-dependent antisense oligonucleotides (ASO)\u003c\/h3\u003e\n\u003cp\u003eOften as 2'-O-MOE\/DNA chimeras that activate RNase H-mediated cleavage of target RNA.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg class=\"rte-list-icon\" viewbox=\"0 0 640 640\"\u003e\n \u003cpath fill=\"currentColor\" d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\"\u003e \u003c\/path\u003e\n \u003c\/svg\u003e Steric-blocking ASO\u003c\/h3\u003e\n\u003cp\u003ePhysically obstructing access to specific RNA molecules, rather than causing their degradation, e.g., splice-switching ASO.\u003csup\u003e[1]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-card\"\u003e\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\u003csvg viewbox=\"0 0 640 640\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"rte-list-icon\"\u003e\u003cpath d=\"M480 64C497.7 64 512 78.3 512 96C512 153.8 487.6 200.8 454.6 240.5C430.5 269.4 400.8 295.6 371 320C400.8 344.5 430.5 370.6 454.6 399.5C487.6 439.1 512 486.2 512 544C512 561.7 497.7 576 480 576C462.3 576 448 561.7 448 544L192 544C192 561.7 177.7 576 160 576C142.3 576 128 561.7 128 544C128 486.2 152.4 439.2 185.4 399.5C209.5 370.6 239.2 344.5 269 320C239.2 295.5 209.5 269.4 185.4 240.5C152.4 200.8 128 153.8 128 96C128 78.3 142.3 64 160 64C177.7 64 192 78.3 192 96L448 96C448 78.3 462.3 64 480 64zM411.5 448L228.6 448C220.4 458.5 213.5 469.1 208 480L432.2 480C426.6 469.1 419.7 458.5 411.6 448zM366 400C351.7 387 336.2 374.2 320 361C303.8 374.1 288.3 387 274 400L366 400zM228.5 192L411.4 192C419.6 181.5 426.5 170.9 432 160L207.9 160C213.5 170.9 220.4 181.5 228.5 192zM274 240C288.3 253 303.8 265.8 320 279C336.2 265.9 351.7 253 366 240L274 240z\"\u003e\u003c\/path\u003e\u003c\/svg\u003e Enzyme or structural RNA inhibition\u003c\/h3\u003e\n\u003cp\u003eInhibit specific RNAs or enzymes (e.g., telomerase) through binding interference.\u003csup\u003e[2]\u003c\/sup\u003e\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eFeatures and Benefits\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh coupling efficiency and reproducibility in solid-phase DNA synthesis \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eHigh purity (≥ 98%) and tightly controlled impurity profiles \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eCompatible with standard DNA\/RNA phosphoramidites \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003eSimplified purification: no special precautions needed against RNase degradation \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\" style=\"margin-bottom: 20px;\"\u003eFast-deprotection variants available upon request \u003csvg width=\"10\" height=\"10\" viewbox=\"0 0 300 300\"\u003e\n \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n \u003c\/svg\u003e\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eOther Notes\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage:\u003c\/strong\u003e Store in a dry, inert atmosphere at -20 °C.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCoupling:\u003c\/strong\u003e 6 minute coupling time recommended\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRecommended deprotection:\u003c\/strong\u003e 8 h at 55 °C in concentrated ammonia, or 10 min at 65 °C in AMA (ammonia\/methylamine, 1:1 v\/v)\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCompatibility:\u003c\/strong\u003e Can be used alongside modified phosphoramidites (e.g., \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-me-phosphoramidites\"\u003e2′-OMe\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-moe-phosphoramidites\"\u003e2′-MOE\u003c\/a\u003e, \u003ca href=\"https:\/\/shop.hongene.com\/collections\/2-o-4-c-locked-na-phosphoramidites\"\u003eLocked-NA\u003c\/a\u003e) to synthesize chimeric oligonucleotides.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003eReference\u003c\/h3\u003e\n\u003cp\u003e\u003ccite\u003e[1] Hill, Alyssa C., and Jonathan Hall. \"The MOE modification of RNA: Origins and widescale impact on the oligonucleotide therapeutics field.\" Helvetica Chimica Acta 106, no. 3 (2023): e202200169.\u003c\/cite\u003e\u003cbr\u003e\u003ccite\u003e[2] Elayadi, Anissa N., Andrea Demieville, Edward V. Wancewicz, Brett P. Monia, and David R. Corey. \"Inhibition of telomerase by 2′-O-(2-methoxyethyl) RNA oligomers: effect of length, phosphorothioate substitution and time inside cells.\" Nucleic Acids Research 29, no. 8 (2001): 1683-1689.\u003c\/cite\u003e\u003c\/p\u003e","brand":"Hongene","offers":[{"title":"N (Normal) \/ 0.25g \/ 30mL screwed bottle-28","offer_id":44541325082824,"sku":"PR4-002-025A","price":15.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 0.5g \/ 30mL screwed bottle-28","offer_id":44541325115592,"sku":"PR4-002-05A","price":21.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 1g \/ 30mL screwed bottle-28","offer_id":44541325148360,"sku":"PR4-002-1A","price":25.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 5g \/ 240mL screwed bottle","offer_id":44541325181128,"sku":"PR4-002-5B","price":68.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 10g \/ 240mL screwed bottle","offer_id":44541325213896,"sku":"PR4-002-10B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 25g \/ 250mL HDPE bottle","offer_id":44541325246664,"sku":"PR4-002-25C","price":295.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 100g \/ 250mL HDPE bottle","offer_id":44541325279432,"sku":"PR4-002-100C","price":975.0,"currency_code":"USD","in_stock":true},{"title":"N (Normal) \/ 200g \/ 500mL HDPE bottle","offer_id":44541325312200,"sku":"PR4-002-200D","price":1800.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR4-002_c84af093-70e5-46eb-9e00-139abb1539d6.jpg?v=1748589697"},{"product_id":"5-me-5-o-dmt-2-o-moe-cr-3-ce-phosphoramidite","title":"5-Me-5'-O-DMT-2'-O-MOE-Cr 3'-CE-Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541325541576,"sku":"PR3-024","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR3-024_eb8115a0-b92f-4a22-88c1-e35bf02f8aba.jpg?v=1748589696"},{"product_id":"abasic-moe-amidite-a-b-mix","title":"Abasic MOE amidite (α, β mix)","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541325574344,"sku":"OP-029","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/OP-029_a055e756-5022-4241-9213-3ffee2093892.jpg?v=1748589695"},{"product_id":"dmt-2-o-moe-ar-ce-phosphoramidite","title":"5'-O-DMT-2'-O-MOE-Ar-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541325607112,"sku":"PR1-017","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR1-017_2478d361-2d30-4a1f-9a70-36b1618f7b29.jpg?v=1748589695"},{"product_id":"2-6-diamino-n2-n6-diibu-dmt-2-o-moe-purine-riboside-ce-phosphoramidite","title":"2,6-diamino (N2, N6-diiBu)-5'-O-DMTr-2'-O-MOE-purine riboside-3'-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541325803720,"sku":"OP-030","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/OP-030_f1da212e-eda3-427d-a27b-a0a236415aed.jpg?v=1748589694"},{"product_id":"dmt-da-bz-ce-reverse-phosphoramidite","title":"DMT-dA(Bz)-CE Reverse Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541325836488,"sku":"PD1-006","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD1-006_c7bbdab0-549e-47b7-b3e4-2ac026dd6277.jpg?v=1748589693"},{"product_id":"dmt-dg-dmf-ce-reverse-phosphoramidite","title":"DMT-dG(dmf)-CE Reverse Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541326328008,"sku":"PD2-005","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD2-005_dce6cf70-c1ff-47fb-b461-225f8804868a.jpg?v=1748589692"},{"product_id":"dmt-dg-ibu-ce-reverse-phosphoramidite","title":"DMT-dG(iBu)-CE Reverse Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541326426312,"sku":"PD2-007","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD2-007_6bedd9b2-1b24-430f-ad77-5aa2ac65430a.jpg?v=1748589691"},{"product_id":"dmt-dc-bz-ce-reverse-phosphoramidite","title":"DMT-dC(Bz)-CE Reverse Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541326557384,"sku":"PD3-004","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD3-004_5088025f-cb7e-4128-bf3c-75b36b5e6751.jpg?v=1748589690"},{"product_id":"dmt-dc-ac-ce-reverse-phosphoramidite","title":"DMT-dC(Ac)-CE Reverse Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541326622920,"sku":"PD3-006","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD3-006_43276a7d-0e98-4ca9-b4a1-499339cf0574.jpg?v=1748589689"},{"product_id":"dmt-dt-ce-reverse-phosphoramidite","title":"DMT-dT-CE Reverse Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541326655688,"sku":"PD4-003","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD4-003_7a75b886-bfca-488c-9312-c05dc1ac36a3.jpg?v=1748589688"},{"product_id":"5-me-dmt-dc-bz-5-ce-reverse-phosphoramidite","title":"5-Me-DMT-dC(Bz) 5'-CE Reverse Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541326721224,"sku":"PD3-018","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD3-018_1acaaf8c-f473-47e2-b2c7-bec7f116d2ec.jpg?v=1748589687"},{"product_id":"2-6-diamino-n2-n6-dipac-dmt-2-o-me-purine-riboside-ce-phosphoramidite","title":"2, 6-diamino (N2, N6-diPac)-DMT-2'-O-Me-purine riboside-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541327048904,"sku":"PR1-005","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR1-005_1b01a5ef-1877-4408-9b31-df6e7222172a.jpg?v=1748589683"},{"product_id":"dmt-da-dma-ce-phosphoramidite","title":"DMT-dA(dma)-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541327212744,"sku":"PD1-005","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD1-005_fe94ed0c-428f-416b-97d0-b9336ecb6f30.jpg?v=1748589682"},{"product_id":"chemical-phosphorylation-reagent","title":"Chemical Phosphorylation Reagent","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541327278280,"sku":"OP-006","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/OP-006_fe710285-343f-47f5-a8b2-086d6a543df1.jpg?v=1748589681"},{"product_id":"5-br-du-phosphoramidite","title":"5-Br-dU-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541327343816,"sku":"PD5-005","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD5-005_b65ae5c2-b540-49ba-967e-e9598301ceaa.jpg?v=1748589680"},{"product_id":"5-cholesterol-ce-phosphoramidite","title":"5'-Cholesterol-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"Plant Source","offer_id":44541327507656,"sku":"OP-014","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/OP-014_4ea0d397-e732-4854-9831-1936f0fc6b27.jpg?v=1748589679"},{"product_id":"5-cholesterol-teg-ce-phosphoramidite","title":"5'-Cholesteryl-Triethylene Glycol-CE Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"Plant 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(Normal)","offer_id":44541328064712,"sku":"PD5-009","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD5-009_cdac9980-cfca-4c8b-a0d6-554281b0e525.jpg?v=1748589676"},{"product_id":"iaa-aminoallyl-du-phosphoramidite","title":"IAA-Aminoallyl-dU Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541328294088,"sku":"PD5-010","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD5-010_af3cfa2e-307e-42c8-9a33-bc619010047c.jpg?v=1748589675"},{"product_id":"phenol-aminoallyl-du-phosphoramidite","title":"Phenol-Aminoallyl-dU Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541328425160,"sku":"PD5-011","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD5-011_722480d5-d3ad-4f14-b3b4-4b6d04a68240.jpg?v=1748589675"},{"product_id":"5-o-dmt-2-o-tbdms-5-ome-ur-phosphoramidite","title":"DMT-2'-O-TBDMS-5-OMe-Ur Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541328490696,"sku":"PR5-022","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PR5-022_e038d758-d34a-4ffd-8936-c86b74119b84.jpg?v=1748589674"},{"product_id":"5-o-dmt-2-o-tbdms-n1-me-pu-phosphoramidite","title":"5'-O-DMT-2'-O-TBDMS-N1-Me-Pseudouridine Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N 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(Normal)","offer_id":44541328851144,"sku":"PD5-020","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD5-020_8e6e01b4-23c7-4349-9b87-f4548db5cda6.jpg?v=1748589671"},{"product_id":"reverse-abasic-phosphoramidite","title":"Reverse Abasic Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N (Normal)","offer_id":44541328916680,"sku":"OP-040","price":0.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/OP-040_5a642e8f-2d6f-48ba-86b2-3b069b67f8ea.jpg?v=1748589670"},{"product_id":"tr-c6-amine-linker-amidite","title":"Tr-C6-amino-linker Phosphoramidite","description":"","brand":"Hongene","offers":[{"title":"N 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