{"product_id":"dmt-2-f-dc-ac-ce-phosphoramidite","title":"DMT-2'-F-dC(Ac)-CE 亚磷酰胺","description":"\u003cstyle\u003e\n.rte-hr {\n    background: linear-gradient(to right, white, #162F65);\n    border: 0;\n    height: 1px;\n    margin-top: 20px;\n}\n.rte-des-lists {\n    display: flex;\n    flex-wrap: wrap;\n    gap: 25px;\n    padding: 0 10px;\n    margin-bottom: 25px;\n}\n.rte-list-card {\n    flex: 1;\n    background: rgba(239, 238, 236, 0.3);\n    border-radius: 10px;\n    padding: 20px;\n    box-shadow: 0px 3px 10px rgba(22, 47, 101, 0.2);\n    transition: transform 0.3s;\n    min-width: 290px;\n    position: relative;\n}\n.rte-list-card:hover {\n    transform: translateY(-5px);\n}\n.rte-list-icon {\n    width: 25px;\n    height: 25px;\n    margin: 0px 5px -5px 0px;\n    fill: currentColor;\n}\n.rte-list-card h3 {\n    font-size: 1.2em;\n    padding-bottom: 8px;\n    margin-bottom: 8px;\n    color: #3361ac;\n}\n.rte-dashed-list-title {\n    border-bottom: dashed rgba(193, 212, 231);\n}\n.rte-list-feature {\n    border-left: solid 3px #3361ac;\n    padding: 3px 0 3px 10px;\n    margin: 0 5px 5px 0;\n}\n.rte-list-feature svg {\n    width: 10px;\n    height: 10px;\n    margin-bottom: -5px;\n    fill: #3361ac;\n}\n.rte-cite cite {\n    display: block;\n    margin-bottom: 8px;\n}\n\u003c\/style\u003e\n\u003cp\u003eDMT-2'-F-dC(Ac)-CE-亚磷酰胺是一种\u003cstrong\u003e2'-氟 (2'-F)\u003c\/strong\u003e亚磷酰胺单体，用于固相寡核苷酸合成。\u003c\/p\u003e\n\u003cp\u003e它包含一个脱氧胞苷 (dC) 糖上的 2'-F 修饰，并带有乙酰 (Ac) 碱基保护、用于 5'-羟基保护的 5'-二甲氧基三苯甲基 (DMT) 基团以及亚磷酸酯上的氰乙基 (CE) 保护基团。\u003c\/p\u003e\n\u003cp\u003e使用 2'-F 亚磷酰胺合成 RNA 寡核苷酸\u003cstrong\u003e可提高\u003c\/strong\u003e与互补序列形成的双链体的\u003cstrong\u003e核酸酶抗性和结合亲和力\u003c\/strong\u003e。\u003c\/p\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003e应用\u003c\/h3\u003e\n\u003cdiv class=\"rte-des-lists\"\u003e\n\n\u003cdiv class=\"rte-list-card\"\u003e\n\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\n\u003csvg viewbox=\"0 0 640 640\" class=\"rte-list-icon\"\u003e\n        \u003cpath d=\"M128 176C128 149.5 149.5 128 176 128C202.5 128 224 149.5 224 176L224 288L128 288L128 176zM240 432C240 383.3 258.1 338.8 288 305L288 176C288 114.1 237.9 64 176 64C114.1 64 64 114.1 64 176L64 464C64 525.9 114.1 576 176 576C213.3 576 246.3 557.8 266.7 529.7C249.7 501.1 240 467.7 240 432zM304.7 499.4C309.3 508.1 321 509.1 328 502.1L502.1 328C509.1 321 508.1 309.3 499.4 304.7C479.3 294 456.4 288 432 288C352.5 288 288 352.5 288 432C288 456.3 294 479.3 304.7 499.4zM361.9 536C354.9 543 355.9 554.7 364.6 559.3C384.7 570 407.6 576 432 576C511.5 576 576 511.5 576 432C576 407.7 570 384.7 559.3 364.6C554.7 355.9 543 354.9 536 361.9L361.9 536z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e 治疗性寡核苷酸\u003c\/h3\u003e\n\n\u003cp\u003e常用于化学修饰的小干扰 RNA (siRNA)，以增强稳定性、效力和体内性能。\u003csup\u003e[1][2]\u003c\/sup\u003e\u003c\/p\u003e\n\n\n\u003c\/div\u003e\n\n\u003cdiv class=\"rte-list-card\"\u003e\n\n\u003ch3 class=\"rte-dashed-list-title\"\u003e\n\n\u003csvg viewbox=\"0 0 640 640\" class=\"rte-list-icon\"\u003e\n        \u003cpath d=\"M406.6 73.4C394.1 60.9 373.8 60.9 361.3 73.4C348.8 85.9 348.8 106.2 361.3 118.7L370.7 128L92.1 406.6C74.1 424.6 64 449 64 474.5L64 480C64 533 107 576 160 576L165.5 576C191 576 215.4 565.9 233.4 547.9L512 269.3L521.4 278.7C533.9 291.2 554.2 291.2 566.7 278.7C579.2 266.2 579.2 245.9 566.7 233.4L406.7 73.4zM269.3 320L416 173.3L466.7 224L370.7 320L269.2 320z\" fill=\"currentColor\"\u003e \u003c\/path\u003e\n      \u003c\/svg\u003e 探针和诊断\u003c\/h3\u003e\n\n\u003cp\u003e用于构建核酸酶抗性高亲和力探针（例如适体），以研究生物分子相互作用\u003csup\u003e[3][4]\u003c\/sup\u003e，这可能与疾病和癌症相关\u003csup\u003e[5][6]\u003c\/sup\u003e。\u003c\/p\u003e\n\n\n\u003c\/div\u003e\n\n\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003e特点和优势\u003c\/h3\u003e\n\u003cdiv class=\"rte-list-feature\"\u003e\n\n\u003cstrong\u003e高纯度\u003c\/strong\u003e：生产纯度≥98%，杂质规格严格控制。 \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003e\n\n\u003cstrong\u003e兼容性\u003c\/strong\u003e：与标准亚磷酰胺化学和大多数商用合成仪兼容。 \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\n\u003c\/div\u003e\n\u003cdiv class=\"rte-list-feature\"\u003e\n\n\u003cstrong\u003e优异的偶联效率和产率\u003c\/strong\u003e。 \u003csvg viewbox=\"0 0 300 300\" height=\"10\" width=\"10\"\u003e\n    \u003cpolygon points=\"50,250 250,50 250,250\"\u003e\u003c\/polygon\u003e\n  \u003c\/svg\u003e\n\n\u003c\/div\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003e其他注意事项\u003c\/h3\u003e\n\u003cul style=\"margin-inline-start: 0; padding-inline-start: 1.35em;\"\u003e\n\n\u003cli\u003e稀释剂：无水乙腈。\u003c\/li\u003e\n\n\u003cli\u003e储存：在 -20 °C 干燥惰性气氛下储存。\u003c\/li\u003e\n\n\u003cli\u003e偶联：建议偶联时间为 6 分钟。\u003c\/li\u003e\n\n\n\u003c\/ul\u003e\n\u003chr class=\"rte-hr\"\u003e\n\u003ch3\u003e参考文献\u003c\/h3\u003e\n\u003cdiv class=\"rte-cite\"\u003e\n\n\u003ccite\u003e[1] Manoharan, M., Akinc, A., Pandey, R.K., Qin, J., Hadwiger, P., John, M., Mills, K., Charisse, K., Maier, M.A., Nechev, L. and Greene, E.M., 2011. Unique gene‐silencing and structural properties of 2′‐fluoro‐modified siRNAs. Angewandte Chemie, 123(10), pp.2332-2336.\u003c\/cite\u003e \u003ccite\u003e[2] Dowler, Thomas, Denis Bergeron, Anna-Lisa Tedeschi, Luc Paquet, Nicolay Ferrari, and Masad J. Damha. \"Improvements in siRNA properties mediated by 2′-deoxy-2′-fluoro-β-D-arabinonucleic acid (FANA).\" Nucleic acids research 34, no. 6 (2006): 1669-1675. \u003c\/cite\u003e \u003ccite\u003e[3] Kratschmer, Christina, and Matthew Levy. \"Effect of chemical modifications on aptamer stability in serum.\" Nucleic acid therapeutics 27, no. 6 (2017): 335-344. \u003c\/cite\u003e \u003ccite\u003e[4] Hervas-Stubbs, Sandra, Mario M. Soldevilla, Helena Villanueva, Uxua Mancheño, Maurizio Bendandi, and Fernando Pastor. \"Identification of TIM3 2′-fluoro oligonucleotide aptamer by HT-SELEX for cancer immunotherapy.\" Oncotarget 7, no. 4 (2015): 4522.\u003c\/cite\u003e \u003ccite\u003e[5] Gruenke, Paige R., Khalid K. Alam, Kamal Singh, and Donald H. Burke. \"2′-fluoro-modified pyrimidines enhance affinity of RNA oligonucleotides to HIV-1 reverse transcriptase.\" RNA 26, no. 11 (2020): 1667-1679.\u003c\/cite\u003e \u003ccite\u003e[6] Lozano, Teresa, Mario Martínez Soldevilla, Noelia Casares, Helena Villanueva, Maurizio Bendandi, Juan Jose Lasarte, and Fernando Pastor. \"Targeting inhibition of Foxp3 by a CD28 2′-Fluro oligonucleotide aptamer conjugated to P60-peptide enhances active cancer immunotherapy.\" Biomaterials 91 (2016): 73-80.\u003c\/cite\u003e\n\n\u003c\/div\u003e","brand":"Hongene","offers":[{"title":"标准 \/ 0.25克\/30毫升 螺口瓶-28","offer_id":44541342646472,"sku":"PD3-001-025A","price":26.0,"currency_code":"USD","in_stock":true},{"title":"标准 \/ 0.5克\/30毫升 螺旋盖瓶-28","offer_id":44541342679240,"sku":"PD3-001-05A","price":34.0,"currency_code":"USD","in_stock":true},{"title":"标准 \/ 1克\/30毫升旋盖瓶-28","offer_id":44541342712008,"sku":"PD3-001-1A","price":38.0,"currency_code":"USD","in_stock":true},{"title":"标准 \/ 5克\/240毫升螺口瓶","offer_id":44541342744776,"sku":"PD3-001-5B","price":115.0,"currency_code":"USD","in_stock":true},{"title":"标准 \/ 10克\/240毫升旋口瓶","offer_id":44541342777544,"sku":"PD3-001-10B","price":190.0,"currency_code":"USD","in_stock":true},{"title":"标准 \/ 25克\/250毫升高密度聚乙烯瓶","offer_id":44541342810312,"sku":"PD3-001-25C","price":475.0,"currency_code":"USD","in_stock":true},{"title":"标准 \/ 100克\/250毫升高密度聚乙烯瓶","offer_id":44541342843080,"sku":"PD3-001-100C","price":1700.0,"currency_code":"USD","in_stock":true},{"title":"标准 \/ 200克\/500毫升高密度聚乙烯瓶","offer_id":44541342875848,"sku":"PD3-001-200D","price":3200.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0682\/8228\/6280\/files\/PD3-001_1df0d116-c052-4ffd-a944-e72d89e35d85.jpg?v=1748589605","url":"https:\/\/shop.hongene.com\/zh\/products\/dmt-2-f-dc-ac-ce-phosphoramidite","provider":"Hongene Online Store","version":"1.0","type":"link"}