2'-O-4'-C-Locked-G(dmf) Phosphoramidite

N2-dimethylformamidine-5'-O-(4, 4'-dimethoxytrityl)-2'-O-4'-C-Locked-Guanosine-3'-cyanoethyl Phosphoramidite
Catalog No. PR2-005
Molecular Formula C44H53N8O8P
Molecular Weight 852.93
Storage Condition -20℃
Purity HPLC≥98.0%

2'-O-4'-C-Locked-G(dmf) Phosphoramidite

N2-dimethylformamidine-5'-O-(4, 4'-dimethoxytrityl)-2'-O-4'-C-Locked-Guanosine-3'-cyanoethyl Phosphoramidite
Grade
Amount/Package: 0.25g / 30mL screwed bottle-28
SKU: PR2-005-025A
Unit price:
$34.00

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$34.00
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Details

Basic Information

Locked Nucleic Acid (LNA) was first described by Wengel and coworkers in 1998 as a novel class of conformationally restricted oligonucleotide analogs

LNA is a bicyclic nucleic acid in which a ribonucleoside is linked to a methylene moiety between the 2'-oxygen and 4'-carbon atoms.

Oligonucleotides containing LNA exhibit unprecedented thermal stability to complementary DNA and RNA, allowing for excellent mismatch discrimination.

Application

LNA phosphoramidites, including 2'-O-4'-C-Locked-G(dmf) Phosphoramidite, offer multiple applicatoin due to their features:

  • The high binding affinity of LNA oligos allows the use of short probes in applications such as SNP genotyping, allele-specific PCR and mRNA sample preparation.
  • LNA is recommended for use in any hybridization assay that requires high specificity and/or reproducibility, such as double-labeled probes, in situ hybridization probes, molecular beacons, and PCR primers.
  • LNA offers the ability to customize the Tm values of primers and probes in multiplexed assays.

As a result of these important properties, the use of LNA-modified oligos in antisense drug design is now being investigated, and recently the therapeutic potential of LNA has been explored.

Other Notes

LNA can be mixed with DNA and RNA, as well as other nucleic acid analogs, modifiers and labels. LNA oligonucleotides are water soluble and can be separated by gel electrophoresis and precipitated by ethanol.

Specifications
  • Catalog No.
    PR2-005
  • SMILES
    O=C1C(N=CN2[C@H]3[C@H](OC4)[C@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@@]4(COC(C5=CC=CC=C5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7)O3)=C2N=C(/N=C/N(C)C)N1
  • Molecular Formula
    C44H53N8O8P
  • Molecular Weight
    852.93
  • Appearance
    Off-white to yellow powder,free from visible foreign matter
  • Purity
    HPLC≥98.0%
  • Storage Condition
    -20℃

Documentation
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Basic Information

Locked Nucleic Acid (LNA) was first described by Wengel and coworkers in 1998 as a novel class of conformationally restricted oligonucleotide analogs

LNA is a bicyclic nucleic acid in which a ribonucleoside is linked to a methylene moiety between the 2'-oxygen and 4'-carbon atoms.

Oligonucleotides containing LNA exhibit unprecedented thermal stability to complementary DNA and RNA, allowing for excellent mismatch discrimination.

Application

LNA phosphoramidites, including 2'-O-4'-C-Locked-G(dmf) Phosphoramidite, offer multiple applicatoin due to their features:

  • The high binding affinity of LNA oligos allows the use of short probes in applications such as SNP genotyping, allele-specific PCR and mRNA sample preparation.
  • LNA is recommended for use in any hybridization assay that requires high specificity and/or reproducibility, such as double-labeled probes, in situ hybridization probes, molecular beacons, and PCR primers.
  • LNA offers the ability to customize the Tm values of primers and probes in multiplexed assays.

As a result of these important properties, the use of LNA-modified oligos in antisense drug design is now being investigated, and recently the therapeutic potential of LNA has been explored.

Other Notes

LNA can be mixed with DNA and RNA, as well as other nucleic acid analogs, modifiers and labels. LNA oligonucleotides are water soluble and can be separated by gel electrophoresis and precipitated by ethanol.

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