PMO

(14 products)

This series is built upon the robust Phosphorodiamidate Morpholino Oligomer (PMO) chemistry and is divided into two lines: PMO Monomer series and PMO Dimer series.

Introduction to PMO

A Phosphorodiamidate Morpholino Oligomer (PMO) is a synthetic nucleic acid analog engineered for superior performance in genetic regulation. Its unique structure features a morpholino ring in place of the sugar moiety and a neutral phosphorodiamidate backbone instead of the negatively charged phosphate backbone found in DNA or RNA.

Key inherent properties of the PMO scaffold include:

  • Exceptional Nuclease Resistance: Highly stable in biological systems, avoiding degradation.
  • High Sequence Specificity: Precisely binds to complementary RNA targets with minimal off-target effects.
  • Excellent Safety Profile: The neutral backbone reduces non-specific binding to proteins, leading to fewer unintended interactions and improved tolerability.

What is PMO Monomer?
The PMO Monomer is the classic, standard-bearer of the technology. It consists of a single, continuous strand of 20-30 morpholino subunits. This line represents a proven and reliable tool for effective gene expression modulation through steric blockade.

Base O N O P N O Cl

General structure of a PMO monomer

What is PMO Dimer?
The PMO Dimer series represents the next generation in antisense technology. It is not a simple mixture but a single molecule where two different PMO sequences are covalently linked end-to-end via a non-nucleotide connector. This innovative architecture allows a single Dimer molecule to target two adjacent sites on the same RNA transcript simultaneously, resulting in a dramatic increase in potency and efficacy.

N O O P O N N O Base Base O P N O Cl

General structure of PMO Dimer

The Role of PMO Monomer and PMO Dimer in Synthesis

In the context of synthesis and manufacturing, both series share a foundation in solid-phase synthesis, but the Dimer presents a more complex and sophisticated process.

  • PMO Monomer Synthesis: The synthesis involves the sequential addition of morpholino subunits to build a single, specific sequence. Our expertise ensures high yield, purity, and accuracy for each custom sequence.
  • PMO Dimer Synthesis: The synthesis is a two-part process. First, two individual PMO "monomer" strands with distinct sequences are synthesized. Second, these two strands are precisely and covalently conjugated through a specialized linker. This requires advanced purification and analytical techniques to guarantee the formation of the correct, single-molecule Dimer product. The synthesis of Dimers is a testament to our advanced chemical capabilities.

Our Advantages

Choosing our PMO Series provides you with a distinct competitive edge:

Unmatched Expertise

We are specialists in PMO chemistry, from foundational Monomers to complex Dimers.

Dual-Technology Platform

We offer both the Monomer and the Dimer technologies, allowing you to select the perfect tool for your specific application, from basic research to clinical development.

High Purity and Quality

Rigorous QC standards ensure that every batch, whether Monomer or Dimer, meets the highest specifications for purity and performance.

Customized Solutions

We provide tailor-made sequences and designs to meet your unique research and development needs.

Application Fields

The PMO Series, both Monomer and Dimer, has broad applications in research, therapeutics, and biotechnology:

Therapeutic Development

Primarily for Exon Skipping therapies in genetic diseases like Duchenne Muscular Dystrophy (DMD). The Dimer series is particularly powerful for challenging targets requiring high efficacy.

Infectious Disease Research

Targeting viral or bacterial RNA to inhibit replication.

Functional Genomics

Used to block gene function by inhibiting translation (anti-sense) or pre-mRNA splicing (splice-switching) in model organisms.

Drug Discovery & Target Validation

Excellent tools for functional characterization of novel genetic targets in vitro and in vivo.

View as
Back to top

Compare /8

My Wishlist