HiXCap™ E1
| Catalog No. | ON-598 |
| Purity | HPLC≥97.0% |
| Molecular Formula | C33H45N15O24P4 (free acid) |
| Molecular Weight | 1159.70 (free acid) |
| Storage Condition | -20±5℃ |
| Remarks | Ethyl Cap |
HiXCap™ E1
HiXCap™ E1 - M (Molecular Biology) / 0.1mL / centrifuge tube is backordered and will ship as soon as it is back in stock.
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Shipping notes
Shipping notes
Details
Details
HiXCap™ E1 is a chemically modified cap analogue that is incorporated into mRNA through co-transcription to ensure that the 5' end of the mRNA forms the correct cap structure, which is a necessary condition for ribosome recognition and translation initiation. Its molecular formula is m7G(5')pppA(2'O-Et)pG.
Download HiXCap™ Brochure for more technical details.
Applications
Significantly enhance the translation efficiency of mRNA.
It can resist degradation by nucleases, prolong the half-life and stability of mRNA within the cell, thereby increasing the protein expression level. The research data indicate that mRNA containing the HiXCapTM designs can improve translation under conditions of immune stress.
Features and Benefits
- High capping efficiency
- Minimized GTP competition
- Improved translation efficiency
- Resistance to decapping enzymes
- Compatibility with delivery systems
- Scalable one-post synthesis and cost-effectiveness
- Enhanced immune evasion
Specifications
Specifications
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Catalog No.ON-598
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SMILES[O-]P(OC[C@H]1O[C@@H](N2C(N=CN=C3N)=C3N=C2)[C@H](OCC)[C@@H]1OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)([O-])=O)(OP(OP(OC[C@H]7O[C@@H](N(C=[N+]8C)C9=C8C([O-])=NC(N)=N9)[C@H](O)[C@@H]7O)([O-])=O)([O-])=O)=O.[xNa+]
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Molecular FormulaC33H45N15O24P4 (free acid)
-
Molecular Weight1159.70 (free acid)
-
PurityHPLC≥97.0%
-
Storage Condition-20±5℃
-
RemarksEthyl Cap
Documentation
Documentation
HiXCap™ E1 is a chemically modified cap analogue that is incorporated into mRNA through co-transcription to ensure that the 5' end of the mRNA forms the correct cap structure, which is a necessary condition for ribosome recognition and translation initiation. Its molecular formula is m7G(5')pppA(2'O-Et)pG.
Download HiXCap™ Brochure for more technical details.
Applications
Significantly enhance the translation efficiency of mRNA.
It can resist degradation by nucleases, prolong the half-life and stability of mRNA within the cell, thereby increasing the protein expression level. The research data indicate that mRNA containing the HiXCapTM designs can improve translation under conditions of immune stress.
Features and Benefits
- High capping efficiency
- Minimized GTP competition
- Improved translation efficiency
- Resistance to decapping enzymes
- Compatibility with delivery systems
- Scalable one-post synthesis and cost-effectiveness
- Enhanced immune evasion
-
Catalog No.ON-598
-
SMILES[O-]P(OC[C@H]1O[C@@H](N2C(N=CN=C3N)=C3N=C2)[C@H](OCC)[C@@H]1OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4O)([O-])=O)(OP(OP(OC[C@H]7O[C@@H](N(C=[N+]8C)C9=C8C([O-])=NC(N)=N9)[C@H](O)[C@@H]7O)([O-])=O)([O-])=O)=O.[xNa+]
-
Molecular FormulaC33H45N15O24P4 (free acid)
-
Molecular Weight1159.70 (free acid)
-
PurityHPLC≥97.0%
-
Storage Condition-20±5℃
-
RemarksEthyl Cap
Why choose Hongene?
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Enjoy enterprise‑grade quality even with small batch orders.
Integrated Supply & Commercial Scale
With nearly 30 years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.
Proprietary Technology & IP
Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.
Rigorous Quality
We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.
Manufacturing Scalability
Hongene operates a 1.67-million-square-foot oligonucleotide manufacturing facility featuring advanced equipment, including multiple OligoPilot™ and OligoProcess™ synthesizers ranging from 10 to 1,800 mmol. Its 48 flexible production lines enable seamless, one-stop scale-up of API production from gram-level quantities to metric tons, achieving purity of ≥98% while supporting compliance with NMPA, FDA, and EMA regulatory requirements.
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Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.
