N1-Me-pUTP, 100mM solution
| Catalog No. | R5-027 |
| CAS No. | 1428903-59-6 |
| Purity | HPLC≥99.0% |
| Molecular Formula | C10H14N2Na3O15P3 |
| Molecular Weight | 564.13 |
| Storage Condition | -20℃, Always avoid freeze-thaw cycles. |
N1-Me-pUTP, 100mM solution
N1-Me-pUTP, 100mM solution - M (Molecular Biology) / 1mL / centrifuge tube is backordered and will ship as soon as it is back in stock.
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Shipping notes
Shipping notes
Details
Details
N1-methyl-pseudouridine-5’-triphosphate (m1ΨTP) is a chemically modified uridine nucleotide designed for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase.
m1ΨTP is an N1-methylated derivative of pseudouridine that preserves base-pairing properties while altering innate immune recognition. When substituted for uridine in IVT, m1Ψ reduces activation of innate immune sensors and enhances translational efficiency of the resulting mRNA.
The 100 mM disodium salt solution provides m1ΨTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.
Applications
IVT & RNA Engineering
Used in IVT systems to generate high-quality and modified mRNA with improved performance.[1][2]
mRNA Therapeutics & Vaccines
Used for the production of therapeutic mRNA, where m1Ψ provides stronger suppression of innate immune responses and supports robust protein expression in vivo.[3][4]
Features
Reference
Specifications
Specifications
-
Catalog No.R5-027R5-027
-
CAS No.1428903-59-61428903-59-6
-
SMILESO=C(N(C)C=C1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=OO=C(N(C)C=C1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O
-
Molecular FormulaC10H14N2Na3O15P3C10H14N2Na3O15P3
-
Molecular Weight564.13564.13
-
AppearanceClear colorless solutionClear colorless solution
-
PurityHPLC≥99.0%HPLC≥99.0%
-
Storage Condition-20℃, Always avoid freeze-thaw cycles.-20℃, Always avoid freeze-thaw cycles.
-
Quality ControlThis lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.This lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.
Documentation
Documentation
N1-methyl-pseudouridine-5’-triphosphate (m1ΨTP) is a chemically modified uridine nucleotide designed for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase.
m1ΨTP is an N1-methylated derivative of pseudouridine that preserves base-pairing properties while altering innate immune recognition. When substituted for uridine in IVT, m1Ψ reduces activation of innate immune sensors and enhances translational efficiency of the resulting mRNA.
The 100 mM disodium salt solution provides m1ΨTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.
Applications
IVT & RNA Engineering
Used in IVT systems to generate high-quality and modified mRNA with improved performance.[1][2]
mRNA Therapeutics & Vaccines
Used for the production of therapeutic mRNA, where m1Ψ provides stronger suppression of innate immune responses and supports robust protein expression in vivo.[3][4]
Features
Reference
-
Catalog No.R5-027R5-027
-
CAS No.1428903-59-61428903-59-6
-
SMILESO=C(N(C)C=C1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=OO=C(N(C)C=C1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O
-
Molecular FormulaC10H14N2Na3O15P3C10H14N2Na3O15P3
-
Molecular Weight564.13564.13
-
AppearanceClear colorless solutionClear colorless solution
-
PurityHPLC≥99.0%HPLC≥99.0%
-
Storage Condition-20℃, Always avoid freeze-thaw cycles.-20℃, Always avoid freeze-thaw cycles.
-
Quality ControlThis lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.This lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.
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