IJM Nanoproducer

Catalog No. DV-02
Remarks Pilot to large-scale

IJM Nanoproducer

Specification
SKU: DV-02
Collections LNP Devices mRNA
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Products on this site:
Currently ship to United States & Canada.
For shipping worldwide, please contact us.
Processment: within 2 business days, if available.
US: 2-8 days (from CA by FedEx).
Canada: 5-10 days (excludes customs delays).

Details

Customized impingement jets mixing skid for Large Production Scale.

Production-scale Impingement Jets Mixing (IJM) Skid for the high flow production of lipid nanoparticles (LNP, microemulsions, etc.)

The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.

The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • up to 16 KNAUER high-pressure dosing pumps 80P
  • up to 16 Coriolis flow meters
  • up to 8 KNAUER IJM mixers
  • Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
  • Outlet manifold for LNP solution
  • Back-seal washing system
  • The frame (stainless steel system 1.4301)
  • Installation & familiarization by KNAUER


  • In addition, we offer for our customers:

  • Customized Technical documentation which is order- and article-related
  • Customer Service before, during, and after the setup
  • FAT (Factory Acceptance Test at KNAUER Berlin)
  • SAT (Site Acceptance Test at customer site
  • Specifications

    • Catalog No.
      DV-02
    • Remarks
      Pilot to large-scale

    Customized impingement jets mixing skid for Large Production Scale.

    Production-scale Impingement Jets Mixing (IJM) Skid for the high flow production of lipid nanoparticles (LNP, microemulsions, etc.)

    The Impingement Jets Mixing (IJM) Large Production Scale Units for high flow production of nanoparticles (LNP, microemulsions, etc.) can be configured with up to eight parallel mixing units depending on customer requirements. Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer.

    Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.

    The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.

    The Impingement Jets Mixing (IJM) Large Production Scale Unit for high flow production of nanoparticles (LNP, microemulsions, etc.) consisting of:

  • up to 16 KNAUER high-pressure dosing pumps 80P
  • up to 16 Coriolis flow meters
  • up to 8 KNAUER IJM mixers
  • Inlet manifolds for lipid/ethanol mixture and mRNA/buffer mixture
  • Outlet manifold for LNP solution
  • Back-seal washing system
  • The frame (stainless steel system 1.4301)
  • Installation & familiarization by KNAUER


  • In addition, we offer for our customers:

  • Customized Technical documentation which is order- and article-related
  • Customer Service before, during, and after the setup
  • FAT (Factory Acceptance Test at KNAUER Berlin)
  • SAT (Site Acceptance Test at customer site
  • Why choose Hongene?

    Trusted Partner in Nucleic Acid

    Integrated Supply & Commercial Scale

    With 26+ years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.

    Proprietary Technology & IP

    Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.

    Rigorous Quality

    We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.

    Manufacturing Scalability

    Hongene operates 1.67 million sq. ft Oligonucleotide Manufacturing Facility, with advanced equipments including multiple OligoPilot™ and OligoProcess™ synthesizers (10-1800 mmol). 48 flexible production lines enable one-stop seamless scaling-up of API production from gram-level to tons and acheive high purity of 98%, meeting NMPA, FDA, and EMA standards.

    Global Business Network

    Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.

    Global Business Distribution
    40+
    Countries & Regions
    3000≈
    Global Clients
    54000+L
    Annual NTP Production
    58+t
    Annual Amidites Production

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