GMP, 200mM Tris Salt Solution

Guanosine 5'-monohosphate, 200mM tris salt solution
Catalog No. R2-065
Purity HPLC≥97.0%
Molecular Formula C10H14N5O8P (free acid)
Molecular Weight 363.22 (free acid)
Storage Condition -20℃
Endotoxin <1 EU/ml

GMP, 200mM Tris Salt Solution

Guanosine 5'-monohosphate, 200mM tris salt solution
Grade
Amount/Package: 1mL / centrifuge tube
SKU: R2-065-ML001-P
Unit price:
$105.00

Price

$105.00
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Currently ship to United States & Canada.
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Details

Guanosine-5’-monophosphate (GMP) is a naturally occurring ribonucleotide composed of guanine, ribose, and a single 5’-phosphate group.

GMP serves as a key biochemical building block in RNA metabolism, enzymatic reactions, and biosynthesis studies.

This product is supplied as a 200 mM aqueous solution in the Tris salt form, providing a stable, mildly alkaline environment (typically pH 7.5-8.5) that enhances compatibility with biochemical and enzymatic assays.


Applications

Enzymatic & Biochemical Assays

Optimized for studies involving RNA polymerases, ligases, kinases, and nucleotide-metabolizing enzymes, where Tris buffering supports consistent pH and reduces ionic inhibition.[1]

Reference Standards & Controls

Serves as a quantitative standard for HPLC, LC–MS, enzyme kinetics, and calibration of nucleotide quantification assays.[2]


Features and Benefits

High purity(≥97%), nuclease-free, and Ultra-low endotoxin: suitable for sensitive biochemical assays.
Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
Tris-buffered solution: provide stable pH and enhanced enzyme compatability for biochemical and molecular biology workflows.

Reference

[1] Staeben, Matt, Karen M. Kleman-Leyer, Andrew L. Kopp, Thane A. Westermeyer, and Robert G. Lowery. "Development and validation of a transcreener assay for detection of AMP-and GMP-producing enzymes." Assay and drug development technologies 8, no. 3 (2010): 339-350. [2] Kvitvang, Hans FN, Kåre A. Kristiansen, and Per Bruheim. "Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts." Journal of Chromatography A 1370 (2014): 70-79.

Specifications

  • Catalog No.
    R2-065
  • SMILES
    OCC(N)(CO)CO.O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])([O-])=O)O3)=C2N=C(N)N1
  • Molecular Formula
    C10H14N5O8P (free acid)
  • Molecular Weight
    363.22 (free acid)
  • Appearance
    Clear colorless to yellow solution
  • Purity
    HPLC≥97.0%
  • Storage Condition
    -20℃
  • Bacterial Endotoxin Test
    <1 EU/ml
  • Quality Control
    This preparation is free of DNase and RNase contamination.

Documentation

Guanosine-5’-monophosphate (GMP) is a naturally occurring ribonucleotide composed of guanine, ribose, and a single 5’-phosphate group.

GMP serves as a key biochemical building block in RNA metabolism, enzymatic reactions, and biosynthesis studies.

This product is supplied as a 200 mM aqueous solution in the Tris salt form, providing a stable, mildly alkaline environment (typically pH 7.5-8.5) that enhances compatibility with biochemical and enzymatic assays.


Applications

Enzymatic & Biochemical Assays

Optimized for studies involving RNA polymerases, ligases, kinases, and nucleotide-metabolizing enzymes, where Tris buffering supports consistent pH and reduces ionic inhibition.[1]

Reference Standards & Controls

Serves as a quantitative standard for HPLC, LC–MS, enzyme kinetics, and calibration of nucleotide quantification assays.[2]


Features and Benefits

High purity(≥97%), nuclease-free, and Ultra-low endotoxin: suitable for sensitive biochemical assays.
Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
Tris-buffered solution: provide stable pH and enhanced enzyme compatability for biochemical and molecular biology workflows.

Reference

[1] Staeben, Matt, Karen M. Kleman-Leyer, Andrew L. Kopp, Thane A. Westermeyer, and Robert G. Lowery. "Development and validation of a transcreener assay for detection of AMP-and GMP-producing enzymes." Assay and drug development technologies 8, no. 3 (2010): 339-350. [2] Kvitvang, Hans FN, Kåre A. Kristiansen, and Per Bruheim. "Assessment of capillary anion exchange ion chromatography tandem mass spectrometry for the quantitative profiling of the phosphometabolome and organic acids in biological extracts." Journal of Chromatography A 1370 (2014): 70-79.

Why choose Hongene?

Trusted Partner in Nucleic Acid

Integrated Supply & Commercial Scale

With 26+ years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.

Proprietary Technology & IP

Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.

Rigorous Quality

We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.

Manufacturing Scalability

Hongene operates 1.67 million sq. ft Oligonucleotide Manufacturing Facility, with advanced equipments including multiple OligoPilot™ and OligoProcess™ synthesizers (10-1800 mmol). 48 flexible production lines enable one-stop seamless scaling-up of API production from gram-level to tons and acheive high purity of 98%, meeting NMPA, FDA, and EMA standards.

Global Business Network

Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.

Global Business Distribution
40+
Countries & Regions
3000≈
Global Clients
54000+L
Annual NTP Production
58+t
Annual Amidites Production

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