5-OMe-UTP, 100mM Solution

5-Methoxy-uridine 5'-triphosphate, trisodium salt Solution
Catalog No. R5-046
Purity HPLC ≥97%
Molecular Formula C10H14N2Na3O16P3
Molecular Weight 580.11
Storage Condition -20℃
Endotoxin <1 EU/ml

5-OMe-UTP, 100mM Solution

5-Methoxy-uridine 5'-triphosphate, trisodium salt Solution
Grade
Amount/Package: 0.1mL / centrifuge tube
SKU: R5-046-UL100-P
Collections:  Modified Triphosphates mRNA Nucleotides Nucleotides for mRNA Other Raw Materials Synthesis Blocks
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$42.50

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    Details

    5-methoxy-uridine-5’-triphosphate (5moUTP) is a chemically modified uridine nucleotide designed for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase.

    RNAs containing 5moU have been shown to exhibit reduced innate immune activation and altered translational properties compared with unmodified uridine.

    The 100 mM disodium salt solution provides 5moU in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

    Applications

    Modified mRNA & IVT Research

    Used in IVT reactions to produce modified mRNA with altered immunogenic and structural properties compared with unmodified RNA.[1][2]

    CRISPR & Genome Editing mRNA

    Enables the production of highly active, low-immunogenic Cas9 mRNA for efficient genome editing in vitro and in vivo.[3]

    Features

    High purity, nuclease-free, and extra-low endotoxin: suitable for sensitive biochemical assays.
    Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
    Stable disodium salt form: ensures consistent pH and long-term storage.

    Reference

    [1] Moradian, Hanieh, Toralf Roch, Larissa Anthofer, Andreas Lendlein, and Manfred Gossen. "Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages." Molecular Therapy Nucleic Acids 27 (2022): 854-869. [2] Drzeniek, Norman Michael, Nourhan Kahwaji, Stephan Schlickeiser, Petra Reinke, Sven Geissler, Hans-Dieter Volk, and Manfred Gossen. "Immuno-engineered mRNA combined with cell adhesive niche for synergistic modulation of the MSC secretome." Biomaterials 294 (2023): 121971. [3] Vaidyanathan, Sriram, Krist T. Azizian, AKM Ashiqul Haque, Jordana M. Henderson, Ayal Hendel, Sabrina Shore, Justin S. Antony et al. "Uridine depletion and chemical modification increase Cas9 mRNA activity and reduce immunogenicity without HPLC purification." Molecular Therapy Nucleic Acids 12 (2018): 530-542.

    Specifications
    • Catalog No.
      R5-046
    • SMILES
      O=C(C(OC)=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O
    • Molecular Formula
      C10H14N2Na3O16P3
    • Molecular Weight
      580.11
    • Appearance
      Clear colorless solution
    • Purity
      HPLC ≥97%
    • Storage Condition
      -20℃
    • Bacterial Endotoxin Test
      <1 EU/ml
    • Quality Control
      This lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.

    Documentation
    COA Contact Us

    5-methoxy-uridine-5’-triphosphate (5moUTP) is a chemically modified uridine nucleotide designed for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase.

    RNAs containing 5moU have been shown to exhibit reduced innate immune activation and altered translational properties compared with unmodified uridine.

    The 100 mM disodium salt solution provides 5moU in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

    Applications

    Modified mRNA & IVT Research

    Used in IVT reactions to produce modified mRNA with altered immunogenic and structural properties compared with unmodified RNA.[1][2]

    CRISPR & Genome Editing mRNA

    Enables the production of highly active, low-immunogenic Cas9 mRNA for efficient genome editing in vitro and in vivo.[3]

    Features

    High purity, nuclease-free, and extra-low endotoxin: suitable for sensitive biochemical assays.
    Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
    Stable disodium salt form: ensures consistent pH and long-term storage.

    Reference

    [1] Moradian, Hanieh, Toralf Roch, Larissa Anthofer, Andreas Lendlein, and Manfred Gossen. "Chemical modification of uridine modulates mRNA-mediated proinflammatory and antiviral response in primary human macrophages." Molecular Therapy Nucleic Acids 27 (2022): 854-869. [2] Drzeniek, Norman Michael, Nourhan Kahwaji, Stephan Schlickeiser, Petra Reinke, Sven Geissler, Hans-Dieter Volk, and Manfred Gossen. "Immuno-engineered mRNA combined with cell adhesive niche for synergistic modulation of the MSC secretome." Biomaterials 294 (2023): 121971. [3] Vaidyanathan, Sriram, Krist T. Azizian, AKM Ashiqul Haque, Jordana M. Henderson, Ayal Hendel, Sabrina Shore, Justin S. Antony et al. "Uridine depletion and chemical modification increase Cas9 mRNA activity and reduce immunogenicity without HPLC purification." Molecular Therapy Nucleic Acids 12 (2018): 530-542.

    Why choose Hongene?

    Trusted Partner in Nucleic Acid

    Enjoy enterprise‑grade quality even with small batch orders.

    Integrated Supply & Commercial Scale

    With nearly 30 years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.

    Proprietary Technology & IP

    Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.

    Rigorous Quality

    We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.

    Manufacturing Scalability

    Hongene operates a 1.67-million-square-foot oligonucleotide manufacturing facility featuring advanced equipment, including multiple OligoPilot™ and OligoProcess™ synthesizers ranging from 10 to 1,800 mmol. Its 48 flexible production lines enable seamless, one-stop scale-up of API production from gram-level quantities to metric tons, achieving purity of ≥98% while supporting compliance with NMPA, FDA, and EMA regulatory requirements.

    Global Business Network

    Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.

    Global Business Distribution
    40+
    Countries & Regions
    ≈3000
    Global Clients
    54000L+
    Annual NTP Production
    58t+
    Annual Amidites Production

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