What are Nucleotides? Nucleotides are organic molecules that serve as the fundamental monomeric units of nucleic acids (DNA and RNA). Each nucleotide consists of three components:
A nitrogenous base (purine or pyrimidine)
A pentose sugar (ribose in RNA, deoxyribose in DNA)
One or more phosphate groups
These molecules not only form the genetic blueprint of all living organisms but also participate in critical cellular processes such as energy transfer (e.g., ATP), signal transduction (e.g., cAMP), and enzyme cofactors (e.g., NAD, FAD).
Synthesis of Nucleotides Nucleotides can be synthesized through two primary pathways:
De Novo Synthesis: Cells build nucleotides from simple precursors (amino acids, carbon dioxide, folate derivatives) in a multi-step, energy-intensive process.
Salvage Pathway: Cells recycle pre-formed bases or nucleosides from degraded nucleic acids or dietary sources, offering metabolic efficiency.
Industrial Production: Our nucleotides are produced using advanced enzymatic synthesis and fermentation technologies. This ensures high purity, scalability, and consistency. Steps include:
Selection of optimized microbial strains
Precise control of fermentation conditions
Downstream purification via chromatography and crystallization
Our Advantages
High Purity & Consistency
Our products undergo rigorous QC testing (HPLC, mass spectrometry) to meet research and industrial standards.
Custom Synthesis
We offer tailored nucleotides (modified bases, labeled isotopes, phosphoramidites) for specialized applications.
Sustainable Production
Our enzymatic synthesis reduces waste and energy consumption, aligning with green chemistry principles.
Technical Expertise
With decades of experience in nucleic acid chemistry, we provide unparalleled customer support and collaboration.
Regulatory Compliance
Our products are manufactured in accordance with ISO, USP, and FDA guidelines, ensuring safety for pharmaceutical and food applications.
Applications of Our Nucleotides
By integrating cutting-edge production with deep scientific expertise, we provide nucleotides that drive innovation from the lab to the market:
Genetic Science & Biotechnology
PCR & DNA Sequencing: High-fidelity dNTPs and modified nucleotides for accurate amplification and NGS.
Gene Editing: CRISPR-Cas systems rely on synthetic nucleotides for guide RNA and repair templates.
Diagnostics: Fluorophore-labeled nucleotides for FISH probes and microarray technologies.
Pharmaceutical Development
Antiviral/Anticancer Drugs: Nucleotide analogs (e.g., remdesivir, azidothymidine) inhibit viral replication or cancer cell proliferation.
mRNA Therapeutics & Vaccines: Cap analogs and modified nucleotides enhance stability and translation efficiency in mRNA-based products.
