pUTP, 100mM solution

Pseudouridine 5'-triphosphate, 100mM solution
Catalog No. R5-022
CAS No. 1175-34-4 (free acid)
Purity HPLC≥97.0%
Molecular Formula C9H12N2Na3O15P3
Molecular Weight 550.10
Storage Condition -20℃

pUTP, 100mM solution

Pseudouridine 5'-triphosphate, 100mM solution
Grade
Amount/Package: 0.1mL / centrifuge tube
SKU: R5-022-UL100-P
Collections:  Diagnostics Modified Triphosphates mRNA NTP for Diagnostics Nucleotides Nucleotides for Diagnostics Nucleotides for mRNA Other Raw Materials Synthesis Blocks
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$52.50

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Details

Pseudouridine-5’-triphosphate (ΨTP) is a naturally occurring, modified uridine nucleotide supplied for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase.

When incorporated into RNA, pseudouridine can reduce innate immune recognition compared with unmodified uridine and improve RNA stability and translational performance.

The 100 mM disodium salt solution provides ΨTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

Applications

RNA Biology & Structural Studies

ΨTP is widely used to investigate the effects of RNA modifications on secondary structure, folding, and stability.[1][2]

IVT & RNA Engineering

Used in IVT systems to generate high-quality and modified mRNA with improved performance.[3]

Features

High purity, nuclease-free, and extra-low endotoxin: suitable for sensitive biochemical assays.
Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
Stable disodium salt form: ensures consistent pH and long-term storage.

Reference

[1] 1.Davis, Darrell R. "Stabilization of RNA stacking by pseudouridine." Nucleic acids research 23, no. 24 (1995): 5020-5026. [2] 2.Kierzek, Elzbieta, Magdalena Malgowska, Jolanta Lisowiec, Douglas H. Turner, Zofia Gdaniec, and Ryszard Kierzek. "The contribution of pseudouridine to stabilities and structure of RNAs." Nucleic acids research 42, no. 5 (2014): 3492-3501. [3] 3.Karikó, Katalin, Hiromi Muramatsu, Frank A. Welsh, János Ludwig, Hiroki Kato, Shizuo Akira, and Drew Weissman. "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability." Molecular therapy 16, no. 11 (2008): 1833-1840.

Specifications
  • Catalog No.
    R5-022
  • CAS No.
    1175-34-4 (free acid)
  • SMILES
    O=C(NC=C1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O
  • Molecular Formula
    C9H12N2Na3O15P3
  • Molecular Weight
    550.10
  • Appearance
    Clear colorless solution
  • Purity
    HPLC≥97.0%
  • Storage Condition
    -20℃
  • Quality Control
    This lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.

Documentation
COA Contact Us

Pseudouridine-5’-triphosphate (ΨTP) is a naturally occurring, modified uridine nucleotide supplied for enzymatic incorporation into RNA during IVT using RNA polymerases such as T7 RNA polymerase.

When incorporated into RNA, pseudouridine can reduce innate immune recognition compared with unmodified uridine and improve RNA stability and translational performance.

The 100 mM disodium salt solution provides ΨTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

Applications

RNA Biology & Structural Studies

ΨTP is widely used to investigate the effects of RNA modifications on secondary structure, folding, and stability.[1][2]

IVT & RNA Engineering

Used in IVT systems to generate high-quality and modified mRNA with improved performance.[3]

Features

High purity, nuclease-free, and extra-low endotoxin: suitable for sensitive biochemical assays.
Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
Stable disodium salt form: ensures consistent pH and long-term storage.

Reference

[1] 1.Davis, Darrell R. "Stabilization of RNA stacking by pseudouridine." Nucleic acids research 23, no. 24 (1995): 5020-5026. [2] 2.Kierzek, Elzbieta, Magdalena Malgowska, Jolanta Lisowiec, Douglas H. Turner, Zofia Gdaniec, and Ryszard Kierzek. "The contribution of pseudouridine to stabilities and structure of RNAs." Nucleic acids research 42, no. 5 (2014): 3492-3501. [3] 3.Karikó, Katalin, Hiromi Muramatsu, Frank A. Welsh, János Ludwig, Hiroki Kato, Shizuo Akira, and Drew Weissman. "Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability." Molecular therapy 16, no. 11 (2008): 1833-1840.

Why choose Hongene?

Trusted Partner in Nucleic Acid

Integrated Supply & Commercial Scale

With 26+ years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.

Proprietary Technology & IP

Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.

Rigorous Quality

We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.

Manufacturing Scalability

Hongene operates 1.67 million sq. ft Oligonucleotide Manufacturing Facility, with advanced equipments including multiple OligoPilot™ and OligoProcess™ synthesizers (10-1800 mmol). 48 flexible production lines enable one-stop seamless scaling-up of API production from gram-level to tons and acheive high purity of 98%, meeting NMPA, FDA, and EMA standards.

Global Business Network

Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.

Global Business Distribution
40+
Countries & Regions
3000≈
Global Clients
54000+L
Annual NTP Production
58+t
Annual Amidites Production

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