5-Me-UTP 100mM Solution

5-Methyl-uridine-5’-triphosphate, sodium salt solution
Catalog No. R5-104
Purity HPLC≥98.0%
Molecular Formula C10H14N2Na3O15P3
Molecular Weight 564.11
Storage Condition Long term (Infrequent use; 1-2 times per month): -70℃. Daily/Weekly use:-20℃

5-Me-UTP 100mM Solution

5-Methyl-uridine-5’-triphosphate, sodium salt solution
Grade
Amount/Package: 0.1mL / centrifuge tube
SKU: R5-104-UL100-P
Collections:  mRNA NTP Nucleotides Nucleotides for mRNA Other Raw Materials Synthesis Blocks
Unit price:
$20.00

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    Details

    5-methyluridine triphosphate (5mUTP) is a chemically modified UTP analog that supports production of methyl-modified RNAs with reduced immunogenicity and improved stability.

    This 100 mM disodium salt solution provides 5mUTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

    Applications

    Modified RNA Synthesis

    In vitro transcription of chemically modified mRNA with reduced innate immune activation.[1]

    RNA Structure & Function Studies

    Structure-function studies of RNA methylation and its impact on RNA-protein interactions.[2]

    Features and Benefits

    High purity(≥98%), nuclease-free, and Ultra-low endotoxin: suitable for sensitive biochemical assays.
    Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
    Stable disodium salt form: ensures consistent pH and long-term storage.

    Reference

    [1] Sioud, Mouldy. "Effects of Nucleoside Modifications on mRNA Translation: Choosing the Right Modifications." In RNA Therapeutics: From siRNA to mRNA Innovations, pp. 127-149. New York, NY: Springer US, 2025. [2] Hur, Sun, Robert M. Stroud, and Janet Finer-Moore. "Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective." Journal of Biological Chemistry 281, no. 51 (2006): 38969-38973.

    Specifications
    • Catalog No.
      R5-104
    • SMILES
      O=C(C(C)=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O
    • Molecular Formula
      C10H14N2Na3O15P3
    • Molecular Weight
      564.11
    • Appearance
      Clear colorless solution
    • Purity
      HPLC≥98.0%
    • Storage Condition
      Long term (Infrequent use; 1-2 times per month): -70℃. Daily/Weekly use:-20℃
    • Quality Control
      This lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.

    Documentation
    COA Contact Us

    5-methyluridine triphosphate (5mUTP) is a chemically modified UTP analog that supports production of methyl-modified RNAs with reduced immunogenicity and improved stability.

    This 100 mM disodium salt solution provides 5mUTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

    Applications

    Modified RNA Synthesis

    In vitro transcription of chemically modified mRNA with reduced innate immune activation.[1]

    RNA Structure & Function Studies

    Structure-function studies of RNA methylation and its impact on RNA-protein interactions.[2]

    Features and Benefits

    High purity(≥98%), nuclease-free, and Ultra-low endotoxin: suitable for sensitive biochemical assays.
    Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
    Stable disodium salt form: ensures consistent pH and long-term storage.

    Reference

    [1] Sioud, Mouldy. "Effects of Nucleoside Modifications on mRNA Translation: Choosing the Right Modifications." In RNA Therapeutics: From siRNA to mRNA Innovations, pp. 127-149. New York, NY: Springer US, 2025. [2] Hur, Sun, Robert M. Stroud, and Janet Finer-Moore. "Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective." Journal of Biological Chemistry 281, no. 51 (2006): 38969-38973.

    Why choose Hongene?

    Trusted Partner in Nucleic Acid

    Enjoy enterprise‑grade quality even with small batch orders.

    Integrated Supply & Commercial Scale

    With nearly 30 years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.

    Proprietary Technology & IP

    Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.

    Rigorous Quality

    We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.

    Manufacturing Scalability

    Hongene operates a 1.67-million-square-foot oligonucleotide manufacturing facility featuring advanced equipment, including multiple OligoPilot™ and OligoProcess™ synthesizers ranging from 10 to 1,800 mmol. Its 48 flexible production lines enable seamless, one-stop scale-up of API production from gram-level quantities to metric tons, achieving purity of ≥98% while supporting compliance with NMPA, FDA, and EMA regulatory requirements.

    Global Business Network

    Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.

    Global Business Distribution
    40+
    Countries & Regions
    ≈3000
    Global Clients
    54000L+
    Annual NTP Production
    58t+
    Annual Amidites Production

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