5-Me-UTP, 100mM Sodium Solution

5-Methyl-uridine-5’-triphosphate, sodium salt solution
Catalog No. R5-104
Purity HPLC≥98%
Molecular Formula C10H14N2Na3O15P3
Molecular Weight 564.11
Storage Condition -20℃

5-Me-UTP, 100mM Sodium Solution

5-Methyl-uridine-5’-triphosphate, sodium salt solution
Grade
Amount/Package: 0.1mL / centrifuge tube
SKU: R5-104-UL100-P
Collections:  mRNA NTP Nucleotides Nucleotides for mRNA Other Raw Materials Synthesis Blocks
Unit price:
$20.00

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Details

5-methyluridine triphosphate (5mUTP) is a chemically modified UTP analog that supports production of methyl-modified RNAs with reduced immunogenicity and improved stability.

This 100 mM disodium salt solution provides 5mUTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

Applications

Modified RNA Synthesis

In vitro transcription of chemically modified mRNA with reduced innate immune activation.[1]

RNA Structure & Function Studies

Structure-function studies of RNA methylation and its impact on RNA-protein interactions.[2]

Features and Benefits

High purity(≥98%), nuclease-free, and Ultra-low endotoxin: suitable for sensitive biochemical assays.
Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
Stable disodium salt form: ensures consistent pH and long-term storage.

Reference

[1] Sioud, Mouldy. "Effects of Nucleoside Modifications on mRNA Translation: Choosing the Right Modifications." In RNA Therapeutics: From siRNA to mRNA Innovations, pp. 127-149. New York, NY: Springer US, 2025. [2] Hur, Sun, Robert M. Stroud, and Janet Finer-Moore. "Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective." Journal of Biological Chemistry 281, no. 51 (2006): 38969-38973.

Specifications
  • Catalog No.
    R5-104
  • SMILES
    O=C(C(C)=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O2)NC1=O
  • Molecular Formula
    C10H14N2Na3O15P3
  • Molecular Weight
    564.11
  • Appearance
    Clear colorless solution
  • Purity
    HPLC≥98%
  • Storage Condition
    -20℃
  • Quality Control
    This lot of NTP has been performance tested in transcription reaction. This preparation is free of DNase and RNase contamination.

Documentation
COA Contact Us

5-methyluridine triphosphate (5mUTP) is a chemically modified UTP analog that supports production of methyl-modified RNAs with reduced immunogenicity and improved stability.

This 100 mM disodium salt solution provides 5mUTP in a highly soluble, ready-to-use form suitable for both routine laboratory applications and high-consistency manufacturing environments.

Applications

Modified RNA Synthesis

In vitro transcription of chemically modified mRNA with reduced innate immune activation.[1]

RNA Structure & Function Studies

Structure-function studies of RNA methylation and its impact on RNA-protein interactions.[2]

Features and Benefits

High purity(≥98%), nuclease-free, and Ultra-low endotoxin: suitable for sensitive biochemical assays.
Ready-to-use: 100 mM solution eliminates the need for weighing and dissolution.
Stable disodium salt form: ensures consistent pH and long-term storage.

Reference

[1] Sioud, Mouldy. "Effects of Nucleoside Modifications on mRNA Translation: Choosing the Right Modifications." In RNA Therapeutics: From siRNA to mRNA Innovations, pp. 127-149. New York, NY: Springer US, 2025. [2] Hur, Sun, Robert M. Stroud, and Janet Finer-Moore. "Substrate recognition by RNA 5-methyluridine methyltransferases and pseudouridine synthases: a structural perspective." Journal of Biological Chemistry 281, no. 51 (2006): 38969-38973.

Why choose Hongene?

Trusted Partner in Nucleic Acid

Integrated Supply & Commercial Scale

With 26+ years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.

Proprietary Technology & IP

Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.

Rigorous Quality

We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.

Manufacturing Scalability

Hongene operates 1.67 million sq. ft Oligonucleotide Manufacturing Facility, with advanced equipments including multiple OligoPilot™ and OligoProcess™ synthesizers (10-1800 mmol). 48 flexible production lines enable one-stop seamless scaling-up of API production from gram-level to tons and acheive high purity of 98%, meeting NMPA, FDA, and EMA standards.

Global Business Network

Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.

Global Business Distribution
40+
Countries & Regions
3000≈
Global Clients
54000+L
Annual NTP Production
58+t
Annual Amidites Production

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