Succinates

(67 products)
O X O DMTrO O HO O B P

General structure of a seccinate

What are Succinates?
Succinates, in the context of oligonucleotide synthesis, refer to succinyl-based linker molecules that are covalently attached to solid supports—such as controlled pore glass (CPG), polystyrene, or other polymeric matrices—to serve as the initial anchoring point for synthesis. These molecules feature a terminal carboxyl group that is activated to form a stable ester or amide bond with the first nucleotide of the growing oligonucleotide chain, enabling efficient and reliable solid-phase synthesis.

Synthesis and Functionalization
Our succinate-functionalized supports are manufactured through a controlled and reproducible process:

  • Support Activation: The solid support (e.g., CPG) is first chemically modified with amino or hydroxyl functional groups to provide reactive sites.
  • Succinylation: Succinic anhydride or its derivatives are reacted with the functionalized support under optimized conditions to form a succinyl monolayer with terminal carboxylic acid groups.
  • Activation and Functionalization: The carboxyl groups are activated (e.g., using NHS or carbodiimide chemistry) to allow covalent coupling to the 3'-end of the first nucleoside (or appropriate modifier), resulting in a stable, synthesis-ready support.
  • Rigorous QC: Each batch is validated for loading capacity, homogeneity, and stability to ensure consistent performance.

Role in Oligonucleotide Synthesis
Succinate-based linkers are essential in solid-phase oligonucleotide synthesis, where they:

  • Serve as a stable, hydrolytically robust anchor between the solid support and the oligonucleotide.
  • Allow for efficient chain elongation under standard phosphoramidite chemistry conditions.
  • Enable clean and complete cleavage of the synthesized oligonucleotide under specific conditions (e.g., ammonium hydroxide treatment).

Our Advantages

We deliver succinate-functionalized supports that offer tangible benefits to researchers and developers:

High and Consistent Loading Capacity

Our supports provide uniform and high functionalization levels, ensuring maximum synthesis yield and reproducibility across batches.

Excellent Stability & Compatibility

Designed to withstand repeated exposure to harsh reagents used in oligonucleotide synthesis, our succinate supports maintain integrity throughout deprotection, capping, and oxidation steps.

Customization Options

We offer tailored functionalization levels and support types (e.g., different pore sizes of CPG, various particle sizes of polystyrene) to match specific synthesis scales and oligonucleotide lengths.

High Performance

Our succinate supports are optimized for use in both research and industrial settings, delivering high-quality oligos with minimal failure sequences.

Applications of Our Succinates

Our products are foundational to a wide spectrum of oligonucleotide-based applications:

Diagnostic Assay Development

  1. PCR Primers and Probes: Production of high-quality primers and hydrolysis probes for quantitative PCR and molecular diagnostics.
  2. Microarrays: Synthesis of oligonucleotides immobilized on slides or beads for genomic and transcriptomic profiling.

Therapeutic Oligonucleotide Production

  1. Antisense Oligonucleotides (ASOs): Manufacture of therapeutic ASOs for targeted gene silencing.
  2. siRNA and miRNA Mimics: Synthesis of short RNA duplexes for RNA interference applications.
  3. Aptamer Development: Generation of structured nucleic acid ligands for therapeutic or diagnostic use.

Research & Discovery

  1. Next-Generation Sequencing (NGS): Production of adapters, barcodes, and other oligos used in library preparation.
  2. Gene Synthesis and Cloning: Synthesis of oligonucleotides for assembly into larger DNA constructs.
  3. Functional Genomics: Manufacture of guide RNAs (gRNAs) for CRISPR-Cas systems.

Chemical Biology & Bioconjugation

  1. Oligonucleotide-Conjugate Synthesis: Succinate supports functionalized with appropriate modifiers enable the introduction of terminal reactive groups (e.g., amines, thiols) for subsequent conjugation to dyes, peptides, or small molecules.
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