ARCA, 100mM Sodium Salt Solution
| Catalog No. | ON-121 |
| CAS No. | 400806-46-4 |
| Purity | HPLC≥95.0% |
| Molecular Formula | C22H32N10O18P3 (free acid) |
| Molecular Weight | 816.5 (free acid) |
| Storage Condition | -20℃ |
ARCA, 100mM Sodium Salt Solution
ARCA, 100mM Sodium Salt Solution - N (Normal) / 0.1mL / centrifuge tube is backordered and will ship as soon as it is back in stock.
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Shipping notes
Shipping notes
Details
Details
Anti Reverse Cap Analog (ARCA) is a chemically modified cap analogue that is incorporated into mRNA through co-transcription to ensure that the 5' end of the mRNA forms the correct cap structure, which is a necessary condition for ribosome recognition and translation initiation. Its molecular formula is 3'-OMe-m7G(5')ppp(5')G.
Applications
Significantly enhance the translation efficiency of mRNA.
It can resist degradation by nucleases, prolong the half-life and stability of mRNA within the cell, thereby increasing the protein expression level. ARCA prevents the reverse insertion of the cap structure through chemical modification, ensuring maximum translation efficiency.
Features and Benefits
- High capping efficiency
- Minimized GTP competition
- Improved translation efficiency
- Resistance to decapping enzymes
- Compatibility with delivery systems
- Scalable one-post synthesis and cost-effectiveness
Specifications
Specifications
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Catalog No.ON-121ON-121
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CAS No.400806-46-4400806-46-4
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SMILESO=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])(OP(OP(OC[C@H]4O[C@@H](N(C=[N+]5C)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4OC)([O-])=O)([O-])=O)=O)O3)=C2N=C(N)N1.[3Na+]O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])(OP(OP(OC[C@H]4O[C@@H](N(C=[N+]5C)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4OC)([O-])=O)([O-])=O)=O)O3)=C2N=C(N)N1.[3Na+]
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Molecular FormulaC22H32N10O18P3 (free acid)C22H32N10O18P3 (free acid)
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Molecular Weight816.5 (free acid)816.5 (free acid)
-
AppearanceClear colorless to faint yellow solutionClear colorless to faint yellow solution
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PurityHPLC≥95.0%HPLC≥95.0%
-
Storage Condition-20℃-20℃
Documentation
Documentation
Anti Reverse Cap Analog (ARCA) is a chemically modified cap analogue that is incorporated into mRNA through co-transcription to ensure that the 5' end of the mRNA forms the correct cap structure, which is a necessary condition for ribosome recognition and translation initiation. Its molecular formula is 3'-OMe-m7G(5')ppp(5')G.
Applications
Significantly enhance the translation efficiency of mRNA.
It can resist degradation by nucleases, prolong the half-life and stability of mRNA within the cell, thereby increasing the protein expression level. ARCA prevents the reverse insertion of the cap structure through chemical modification, ensuring maximum translation efficiency.
Features and Benefits
- High capping efficiency
- Minimized GTP competition
- Improved translation efficiency
- Resistance to decapping enzymes
- Compatibility with delivery systems
- Scalable one-post synthesis and cost-effectiveness
-
Catalog No.ON-121ON-121
-
CAS No.400806-46-4400806-46-4
-
SMILESO=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])(OP(OP(OC[C@H]4O[C@@H](N(C=[N+]5C)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4OC)([O-])=O)([O-])=O)=O)O3)=C2N=C(N)N1.[3Na+]O=C1C(N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](COP([O-])(OP(OP(OC[C@H]4O[C@@H](N(C=[N+]5C)C6=C5C(NC(N)=N6)=O)[C@H](O)[C@@H]4OC)([O-])=O)([O-])=O)=O)O3)=C2N=C(N)N1.[3Na+]
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Molecular FormulaC22H32N10O18P3 (free acid)C22H32N10O18P3 (free acid)
-
Molecular Weight816.5 (free acid)816.5 (free acid)
-
AppearanceClear colorless to faint yellow solutionClear colorless to faint yellow solution
-
PurityHPLC≥95.0%HPLC≥95.0%
-
Storage Condition-20℃-20℃
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