DMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite

N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine-3'-cyanoethyl Phosphoramidite
Catalog No. PR1-004
CAS No. 251647-53-7
Molecular Formula C50H58N7O9P
Molecular Weight 932.03
Storage Condition -20℃
Purity HPLC≥98.0%

DMT-2'-O-MOE-A(Bz)-CE-Phosphoramidite

N6-benzoyl-5'-O-(4, 4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine-3'-cyanoethyl Phosphoramidite
Grade
Amount/Package: 0.25g / 30mL screwed bottle-28
SKU: PR1-004-025A
Collections:  2'-O-MOE Phosphoramidites Oligo Synthesis Phosphoramidites Synthesis Blocks
Unit price:
$15.00

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Details

Application

The incorporation of 2′O-Methyl RNA nucleoside, including DMT-2′O-MOE-A(Bz)-C-phosphoramidite, in nucleic acid probes with RNA or DNA is advantageous for in-vivo or in-vitro applications, as it allows for the delivery of nuclease-resistant materials.

Features and Benefits

The product's key features are listed below:

  • High yield of crude oligonucleotides
  • Compatible with DNA synthesis
  • Can be used in conjunction with DNA or RNA phosphoramidites in the same synthesis to produce mixed oligonucleotides
  • Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA (concentrated ammonia/ 40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
  • Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolytic degradation
  • Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6 minutes compared to 90 seconds for DNA monomers)
  • 2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

Other Notes

The distinctive characteristics of 2′O-methyl RNA have led to its extensive utilization in various fields, including:

  • Diagnostic probes
  • Aptamer and ribozyme development
  • Mixed 2′O-Methyl-RNA/DNA antisense molecules

Specifications
  • Catalog No.
    PR1-004
  • CAS No.
    251647-53-7
  • SMILES
    CC(C)N(C(C)C)P(OCCC#N)O[C@H]1[C@@H](OCCOC)[C@H](N(C=N2)C3=C2C(NC(C4=CC=CC=C4)=O)=NC=N3)O[C@@H]1COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7
  • Molecular Formula
    C50H58N7O9P
  • Molecular Weight
    932.03
  • Appearance
    White to off-white powder
  • Purity
    HPLC≥98.0%
  • Storage Condition
    -20℃

Documentation
COA Contact Us
Spec Download

Application

The incorporation of 2′O-Methyl RNA nucleoside, including DMT-2′O-MOE-A(Bz)-C-phosphoramidite, in nucleic acid probes with RNA or DNA is advantageous for in-vivo or in-vitro applications, as it allows for the delivery of nuclease-resistant materials.

Features and Benefits

The product's key features are listed below:

  • High yield of crude oligonucleotides
  • Compatible with DNA synthesis
  • Can be used in conjunction with DNA or RNA phosphoramidites in the same synthesis to produce mixed oligonucleotides
  • Recommended deprotection conditions are 8 hours at 55 °C using concentrated ammonia solution, or with AMA (concentrated ammonia/ 40% aqueous methylamine I/I, v/v) for 10 minutes at 65 °C
  • Purification and other downstream processing of fully modified 2′OMethyl RNA oligonucleotides are simpler than in the case of RNA, as no special precautions are required to provide protection against nucleolytic degradation
  • Synthesis of 2′O-Methyl RNA oligonucleotides is similar to standard DNA synthesis but requires an elongated coupling time (recommended is 6 minutes compared to 90 seconds for DNA monomers)
  • 2′O-Methyl RNA phosphoramidites are also available with fast deprotection chemistry

Other Notes

The distinctive characteristics of 2′O-methyl RNA have led to its extensive utilization in various fields, including:

  • Diagnostic probes
  • Aptamer and ribozyme development
  • Mixed 2′O-Methyl-RNA/DNA antisense molecules

Why choose Hongene?

Trusted Partner in Nucleic Acid

Integrated Supply & Commercial Scale

With 26+ years of expertise, we control a secure supply chain for RNA raw materials and provide reliable GMP-grade oligo synthesis from research to commercial kilogram-scale production.

Proprietary Technology & IP

Our proprietary Chemoenzymatic Ligation Platform combines chemical andenzymatic methods, enabling high-putity, cost-effective, and large-scale production of RNA-based therapeutics.

Rigorous Quality

We implement multiple stringent QC steps, maintain ISO certifications, and ensure >99% batch-to-batch consistency, reducing scale-up and PPQ risks.

Manufacturing Scalability

Hongene operates 1.67 million sq. ft Oligonucleotide Manufacturing Facility, with advanced equipments including multiple OligoPilot™ and OligoProcess™ synthesizers (10-1800 mmol). 48 flexible production lines enable one-stop seamless scaling-up of API production from gram-level to tons and acheive high purity of 98%, meeting NMPA, FDA, and EMA standards.

Global Business Network

Our products and services reach over 40 countries and regions, supporting around 3,000 clients worldwide.

Global Business Distribution
40+
Countries & Regions
3000≈
Global Clients
54000+L
Annual NTP Production
58+t
Annual Amidites Production
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